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Chapter and Conference Paper
Investigation of the Validity of Quantitative Determination of Cadmium and Lead in Human Hair by Atomic Absorption Spectroscopy
Heavy metals occur in increasing amounts in the human environment. There is growing evidence for their role in the development of several diseases. “Biological monitoring” is an established tool in investigati...
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Article
Modifying effects of disulfiram on DNA adduct formation and persistence of benzaldehyde in N-nitroso-N-methyl-benzylamine-induced carcinogenesis in rats
Whereas disulfiram (DSF) is known to inhibit tumor formation resulting from a number of chemical carcinogens, such inhibition does not apply to nitrosamines. In the present study, biochemical and morphological...
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Article
Histogenesis of the bronchiolo/Alveolar carcinoma resulting from modification of N-nitroso-Di-N-butylamine organotropism by disulfiram
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Article
Nitrite: A Co-carcinogen?
The concurrent administration of N-nitroso-N-methylbenzylamine (NMBA) (10 mg/l drinking water) and sodium nitrite (5 g or 1 g/kg basic diet) induces enhanced progression of esophageal tumors. Pathologic changes o...
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Article
Wirkung von Disulfiram auf die Toxizität und Carcinogenität von N-Methyl-N-nitrosobenzylamin bei Ratten
The concurrent application of disulfiram (710 mg/kg diet; or 200 mg/kg diet) effects a strong enhancement of the toxicity and an acceleration of the formation of esophageal tumors by N-methyl-N-nitrosobenzylam...
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Article
Vergleichende Untersuchungen über die organotrope carcinogene Wirkung verschiedener N-Nitrosoverbindungen nach einmaliger bzw. langzeitiger Applikation bei Ratten
After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carc...
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Article
Veränderung der Toxizität und Carcinogenität von N-Methyl-N-nitrosobenzylamin durch Methylsubstitution am Phenylrest bei Ratten
Substitution with a methyl group in the 2-, 3- or 4-position respectively of the phenyl moiety of N-methyl-N-nitrosobenzylamine results in a considerable reduction of the acute toxicity. (LD 50 of MNBA: 18 mg/...
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Article
Untersuchungen über die Nitrosierbarkeit von Nicotin und Nornicotin und über die Frage der Bildung von N-Nitrosonornicotin im Magen von Rauchern
It was examined how easily the tobacco-smoke constituents, nornicotine, and nicotine, are nitrosated in an acidic aqueous medium, and if a formation of nitrosamines in the stomach of smokers is possible after ...
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Article
Tumorinduktion bei Mäusen durch N-Methylbenzyl-nitrosamin in niedriger Dosierung
Tumors of the esophagus and fore-stomach were induced in mice by adding methylbenzylnitrosamine to the drinking water for a limited period of time, the total doses being 1,4–44 mg/kg body weight. No esophageal...
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Article
Untersuchungen zur Frage einer Akkumulation mit Nitrosaminen in Weizen nach gleichzeitiger Düngung mit Nitrat und sekundären Aminen
Experiments were carried out on the problem of nitrosamine accumulation in wheat that was fertilized with compounds containing high doses of nitrate. Wheat was cultivated on a field divided into lots, over whi...