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  1. No Access

    Article

    Modifying effects of disulfiram on DNA adduct formation and persistence of benzaldehyde in N-nitroso-N-methyl-benzylamine-induced carcinogenesis in rats

    Whereas disulfiram (DSF) is known to inhibit tumor formation resulting from a number of chemical carcinogens, such inhibition does not apply to nitrosamines. In the present study, biochemical and morphological...

    F. Schweinsberg, S. Danecki, J. Grotzke… in Journal of Cancer Research and Clinical On… (1986)

  2. Article

    Histogenesis of the bronchiolo/Alveolar carcinoma resulting from modification of N-nitroso-Di-N-butylamine organotropism by disulfiram

    V. Bürkle, H. Wittenberg, F. Schweinsberg in Journal of Cancer Research and Clinical On… (1986)

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  3. No Access

    Article

    Nitrite: A Co-carcinogen?

    The concurrent administration of N-nitroso-N-methylbenzylamine (NMBA) (10 mg/l drinking water) and sodium nitrite (5 g or 1 g/kg basic diet) induces enhanced progression of esophageal tumors. Pathologic changes o...

    F. Schweinsberg, V. Bürkle in Journal of Cancer Research and Clinical Oncology (1985)

  4. No Access

    Article

    Wirkung von Disulfiram auf die Toxizität und Carcinogenität von N-Methyl-N-nitrosobenzylamin bei Ratten

    The concurrent application of disulfiram (710 mg/kg diet; or 200 mg/kg diet) effects a strong enhancement of the toxicity and an acceleration of the formation of esophageal tumors by N-methyl-N-nitrosobenzylam...

    F. Schweinsberg, V. Bürkle in Journal of Cancer Research and Clinical Oncology (1981)

  5. No Access

    Article

    Vergleichende Untersuchungen über die organotrope carcinogene Wirkung verschiedener N-Nitrosoverbindungen nach einmaliger bzw. langzeitiger Applikation bei Ratten

    After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carc...

    F. Schweinsberg, M. Kouros, K. Manncke in Journal of Cancer Research and Clinical Oncology (1979)

  6. No Access

    Article

    Veränderung der Toxizität und Carcinogenität von N-Methyl-N-nitrosobenzylamin durch Methylsubstitution am Phenylrest bei Ratten

    Substitution with a methyl group in the 2-, 3- or 4-position respectively of the phenyl moiety of N-methyl-N-nitrosobenzylamine results in a considerable reduction of the acute toxicity. (LD 50 of MNBA: 18 mg/...

    F. Schweinsberg, Petra Schott-Kollat… in Zeitschrift für Krebsforschung und Klinisc… (1977)

  7. No Access

    Article

    Untersuchungen über die Nitrosierbarkeit von Nicotin und Nornicotin und über die Frage der Bildung von N-Nitrosonornicotin im Magen von Rauchern

    It was examined how easily the tobacco-smoke constituents, nornicotine, and nicotine, are nitrosated in an acidic aqueous medium, and if a formation of nitrosamines in the stomach of smokers is possible after ...

    F. Schweinsberg, J. Sander, E. Schweinsberg… in Zeitschrift für Krebsforschung und Klinisc… (1975)

  8. No Access

    Article

    Tumorinduktion bei Mäusen durch N-Methylbenzyl-nitrosamin in niedriger Dosierung

    Tumors of the esophagus and fore-stomach were induced in mice by adding methylbenzylnitrosamine to the drinking water for a limited period of time, the total doses being 1,4–44 mg/kg body weight. No esophageal...

    J. Sander, F. Schweinsberg in Zeitschrift für Krebsforschung und Klinische Onkologie (1973)

  9. No Access

    Article

    Untersuchungen zur Frage einer Akkumulation mit Nitrosaminen in Weizen nach gleichzeitiger Düngung mit Nitrat und sekundären Aminen

    Experiments were carried out on the problem of nitrosamine accumulation in wheat that was fertilized with compounds containing high doses of nitrate. Wheat was cultivated on a field divided into lots, over whi...

    J. Sander, B. Aeikens, F. Schweinsberg… in Zeitschrift für Krebsforschung und Klinisc… (1973)