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Article
Clinical Meaningfulness in Alzheimer’s Disease Clinical Trials. A Report from the EU-US CTAD Task Force
Recent positive results of three phase III anti-amyloid monoclonal antibody trials are transforming the landscape of disease-modifying therapeutics for Alzheimer’s disease, following several decades of failure...
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Article
Lecanemab: Appropriate Use Recommendations — A Commentary from a European Perspective
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Article
Open AccessWhat Matters to Patients with Alzheimer’s Disease and Their Care Partners? Implications for Understanding the Value of Future Interventions
Alzheimer’s Disease (AD) is the most common cause of dementia. Recent thinking portrays AD as a continuum consisting of three stages: an asymptomatic preclinical period, a mild cognitive impairment phase, and ...
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Article
Open AccessDietary patterns are related to cognitive functioning in elderly enriched with individuals at increased risk for Alzheimer’s disease
To investigate cross-sectional associations between dietary patterns and cognitive functioning in elderly free of dementia.
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Open AccessTargeting Lifestyle Behavior to Improve Brain Health: User-Experiences of an Online Program for Individuals with Subjective Cognitive Decline
Online programs targeting lifestyle have the potential to benefit brain health. We aimed to develop such a program for individuals with subjective cognitive decline (SCD). These individuals were reported to be...
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Article
Open AccessHealth Literacy in Individuals at Risk for Alzheimer’s Dementia: A Systematic Review
Health literacy (HL) refers to the capacity to access, understand, appraise and apply information for decision-making and acting in health-related matters. In the field of Alzheimer’s disease (AD), expanding t...
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Article
Characterization of Cerebellar Atrophy and Resting State Functional Connectivity Patterns in Sporadic Adult-Onset Ataxia of Unknown Etiology (SAOA)
Sporadic adult-onset ataxia of unknown etiology (SAOA) is a non-genetic neurodegenerative disorder of the cerebellum of unknown cause which manifests with progressive ataxia without severe autonomic failure. A...
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Article
Probandenverfügung in der Arzneimittelforschung
Mit dem Vierten Gesetz zur Änderung arzneimittelrechtlicher und anderer Vorschriften im November 2016 hat der Gesetzgeber in Anlehnung an das Instrument der Patientenverfügung zur Ermöglichung gruppennütziger ...
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Article
Leitliniengerechte stationäre psychiatrisch-psychotherapeutische Behandlung psychischer und Verhaltenssymptome bei Demenz
Demenzen sind Erkrankungen zunehmender medizinischer und gesellschaftlicher Relevanz. Insbesondere psychische und Verhaltenssymptome einer Demenz („behavioral and psychological symptoms of dementia“, BPSD) mac...
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Article
Does visual impairment affect social ties in late life? Findings of a multicenter prospective cohort study in Germany
To investigate how visual impairment affects social ties in late life longitudinally.
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Article
Open AccessGenome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment
Few data are available concerning the role of risk markers for Alzheimer’s disease (AD) in progression to AD dementia among subjects with mild cognitive impairment (MCI). We therefore investigated the role of ...
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Article
Predictors of frailty in old age–results of a longitudinal study
To investigate time-dependent predictors of frailty in old age longitudinally.
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Open AccessEffects of deep brain stimulation on prepulse inhibition in obsessive-compulsive disorder
Owing to a high response rate, deep brain stimulation (DBS) of the ventral striatal area has been approved for treatment-refractory obsessive-compulsive disorder (tr-OCD). Many basic issues regarding DBS for t...
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Angebote zur Früherkennung von Psychosen und bipolaren Störungen in Deutschland
Die Verbesserung des Wahrnehmens und Erkennens schwerer psychiatrischer Erkrankungen und die Etablierung von niedrigschwelligen sowie kurzfristig verfügbaren Angeboten für die Diagnostik und Therapie sind Grun...
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Article
Prädiktion der Alzheimer-Demenz
Die Prädiktion der Alzheimer-Demenz ist zunehmend relevant für die Entwicklung von Präventionsstudien und -strategien, aber auch im klinischen Kontext, da häufig von Patienten nach den Vorhersagemöglichkeiten ...
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Article
Trap** of ultracold atoms in a 3He/4He dilution refrigerator
We describe the preparation of ultracold atomic clouds in a dilution refrigerator. The closed-cycle 3He/4He cryostat was custom made to provide optical access for laser cooling, optical manipulation and detectio...
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Article
Open AccessFollow-up of loci from the International Genomics of Alzheimer’s Disease Project identifies TRIP4 as a novel susceptibility gene
To follow-up loci discovered by the International Genomics of Alzheimer’s Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ...
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Article
Potenziell inadäquate Medikamente bei älteren hausärztlich versorgten Patientinnen und Patienten
Ältere Menschen sind oftmals durch mehrere Krankheiten belastet. Mit der daraus resultierenden mehrfachen Medikamenteneinnahme steigt das Risiko für unerwünschte Arzneimittelereignisse. Mit Wirkstofflisten (Be...
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Article
A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI
Mild cognitive impairment (MCI) is etiologically heterogeneous, and a substantial proportion of MCI subjects will develop different dementia disorders. One subtype of this syndrome, amnestic MCI, occurs prefer...
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Article
Reliabilität ärztlicher Morbiditätsangaben zu chronischen Krankheiten
Prävalenzangaben zu chronischen Erkrankungen sind wichtige Daten zur Planung von Versorgungs- und Vergütungsstrukturen. Mit Patienten-Selbstreport-, Abrechnungs- und Studiendokumentationsdaten stehen Angaben z...
