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  1. No Access

    Chapter and Conference Paper

    Rökan beim experimentellen Hirnödem

    Das Hirnödem ist sowohl eine der wesentlichen Komplikationen der cerebralen Ischämie als auch aggravierender Faktor. Die erste Ödemphase verläuft intracellulär und cytotoxisch; der Energiemangel bedingt eine I...

    A. Etienne, F. Hecquet, F. Clostre in Rökan Ginkgo biloba EGb 761 (1991)

  2. No Access

    Chapter and Conference Paper

    Rökan bei der cerebralen Ischämie der Springmaus

    Die Wüstenspringmaus ist wegen der besonderen anatomischen Verhältnisse — diese Species besitzt keine cerebrobasilären Gefäße — ein Modell der Wahl für experimentelle Studien der akuten cerebralen Ischämie. Ei...

    B. Spinnewyn, N. Blavet, F. Clostre in Rökan Ginkgo biloba EGb 761 (1991)

  3. No Access

    Chapter and Conference Paper

    Effects of Ginkgo Biloba Extract on a Cerebral Ischemia Model in Gerbils

    Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia.

    B. Spinnewyn, N. Blavet, F. Clostre in Rökan (1988)

  4. No Access

    Chapter and Conference Paper

    Mechanisms of Effect of Ginkgo Biloba Extract on Experimental Cerebral Edema

    Oedema is one of the major complication of cerebral ischaemia being at the same time a consequence and an aggravating factor.Its firstphase is intracellular and cytotoxic, with breakdown of ionic pumps through...

    A. Etienne, F. Hecquet, F. Clostre in Rökan (1988)

  5. No Access

    Chapter and Conference Paper

    The Pharmacological Bases for the Vascular Impact of Ginkgo Biloba Extract

    The preferential tissue irrigatory effect of Ginkgo biloba extract in ischaemic areas is largely explained by the direct impact of this product on both arteries and veins.

    M. Auguet, S. Delaflotte, A. Hellegouarch, F. Clostre in Rökan (1988)

  6. No Access

    Chapter and Conference Paper

    From the Body to the Cellular Membranes: The Different Levels of Pharmacological Action of Ginkgo Biloba Extract

    The pharmacological study of Ginkgo biloba extract has required numerous experiments over several years: different pathological models of cerebral ischaemia to evaluate its effects, and experiments at both cel...

    F. Clostre in Rökan (1988)

  7. No Access

    Article

    In vivo inhibition of plasma protein leakage andSalmonella enteritidis—induced mortality in the rat by a specific paf-acether antagonist: BN 52021

    The effects of BN 52021, a new specific paf-acether receptor antagonist and the total Ginkgo biloba extract (GBE 761) from which this product was isolated, were studied in the rat on paf-acether-induced permea...

    A. Etienne, F. Hecquet, C. Soulard, B. Spinnewyn, F. Clostre… in Agents and Actions (1986)

  8. No Access

    Article

    Differences in the development of sensitization to norepinephrine between isolated aortas of untreated and reserpinized rabbits

    1. Successive cumulative concentration-response curves for the contractile action of norepinephrine (NE) were co...

    M. Auguet, F. V. DeFeudis, F. Clostre in Pflügers Archiv (1982)

  9. No Access

    Article

    Inhibition of food intake in the rat by cyproheptadine

    In a model of conditioned feeding behavior, oral administration of cyproheptadine (1–100 mg/kg), 30 min before presentation of food, produced a dose-dependent reduction of food intake in the rat (ED50≃17 mg/kg du...

    N. Blavet, F. V. DeFeudis, F. Clostre in Experientia (1982)