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Article
Models for Assessing the Cost-Effectiveness of the Treatment and Prevention of Osteoporosis
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Article
Uncertain Future of Trials in Osteoporosis
The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are availab...
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Article
Acute and Long-Term Increase in Fracture Risk after Hospitalization for Vertebral Fracture
The aims of this study were to determine the magnitude of the increase in risk of further fracture following hospitalization for vertebral fracture, and in particular to determine the time course of this risk...
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Article
A comparison of spinal quantitative computed tomography with dual energy X-ray absorptiometry in European women with vertebral and nonvertebral fractures
Quantitative computed tomography (QCT) was compared to dual X-ray absorptiometry (DXA) measured in the lumbar spine of 508 European women defined as normal without fracture (NoF), or osteoporotic (OP), with ei...
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Article
Quality of Life in Patients with Vertebral Fractures: Validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO)
Vertebral fractures may be minor or lead to pain, decreased physical function, immobility, social isolation and depression, which together contribute to quality of life. A Working Party of the European Founda...
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Article
Quality of life as outcome in the treatment of osteoporosis: The development of a questionnaire for quality of life by the European foundation for osteoporosis
The morbidity of osteoporosis is caused by fractures. Vertebral fractures lead to pain and disability and a decrease in quality of life. A Working Party of the European Foundation for Osteoporosis has develope...
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Article
Effect of Salmon Calcitonin on Femoral Bone Quality in Adult Ovariectomized Ewes
The aim of this study was to evaluate the effect of intermittent calcitonin on femoral bone quality in adult ewes from the time of ovariectomy. Six months after the start of the experiment, bone density measu...
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Article
Plasma Concentration of Estradiol After Transdermal Administration of Systen®50 (Evorel®) or Menorest®50
Circulating plasma levels of 17β-estradiol after the administration of fixed dosages of 17β-estradiol show great variability depending upon product formulation, route of administration, and interindividual var...
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Article
The validation of the effo questionnaire for quality of life in patients with vertebral osteoporosis (Qualeffo)
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Article
Ineffectiveness of calcitonin on a local-disuse osteoporosis in the sheep: A histomorphometric study
Local immobilization is a good model for studying disuse-induced bone loss and to appreciate the effects of drugs, especially preventive action of antiresorptive therapy. In fact, increased osteoclastic activi...
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Article
Effects of a one-year administration of phosphate and intermittent calcitonin on bone-forming and bone-resorbing cells in involutional osteoporosis: A histomorphometric study
The bone histomorphometric effects of intermittent phosphate and calcitonin therapy during 1 year were analyzed in 15 involutional osteoporotic patients. Phosphate was administered continuously (1.5 g/day) and...
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Article
Bone loss and bone blood flow in paraplegic rats treated with calcitonin, diphosphonate, and indomethacin
Sham-operated (SO) and paraplegic rats were treated from the day of operation during a period of 4 or 6 weeks with salmon calcitonin 4 IU/kg/day or a diphosphonate (APD) 1mM/kg/day or indomethacin 2.5 mg/kg/da...
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Chapter and Conference Paper
Chymodiactin
The use of chymopapain in chemonucleolysis of the herniated disc responsible for sciatica, began in July 1963 when Lyman Smith injected the first human subject. The procedure was utilized in more than 16000 patie...
