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  1. No Access

    Article

    Synthesis, biological and biochemical properties of new anthracyclines modified in the aminosugar moiety

    New 4′-C-methyl analogues of daunorubicin, synthesized by the coupling reaction of daunomycinone with 1-chloroderivatives of protected 4-C-methyldaunosamine analogues, were chemically transformed to the corres...

    A. Bargiotti, A. M. Casazza, G. Cassinelli… in Cancer Chemotherapy and Pharmacology (1983)

  2. No Access

    Chapter

    Structure-Activity Relationships in Doxorubicin Related Compounds

    Doxorubicin (Ia) belongs to the anthracycline family of antibiotics, not rarely encountered as pigmented products of the metabolism in cultures of different species of the genus Streptomyces. The classical anthra...

    F. Arcamone in Structure-Activity Relationships of Anti-Tumour Agents (1983)

  3. No Access

    Chapter

    Doxorubicin and Related Compounds. I. Physicochemical Characterization of the DNA Complex

    The study of molecular interactions between drugs and biological macromolecules in solution has received considerable attention in recent years. Researchers in this field of biophysical chemistry, although wel...

    F. Arcamone, E. Arlandini, M. Menozzi… in Anthracycline Antibiotics in Cancer Therapy (1982)

  4. No Access

    Chapter

    Doxorubicin and Related Compounds. II. Structure-Activity Considerations

    In the last ten years several anthracycline glycosides related to doxorubicin have been obtained by semisynthesis, partial synthesis, total synthesis, biosynthesis and tested for “in vitro” and “in vivo” antit...

    F. Arcamone, A. Casazza, G. Cassinelli… in Anthracycline Antibiotics in Cancer Therapy (1982)

  5. No Access

    Article

    Synthesis and antitumour activity of new daunorubicin and adriamycin analogues

    A new synthetic procedure for the preparation of daunorubicin and adriamycin analogues bearing different substituents on ring D, has been developed. The new compounds display outstanding efficacy against exper...

    F. Arcamone, L. Bernardi, B. Patelli, P. Giardino, A. Di Marco… in Experientia (1978)

  6. No Access

    Chapter

    Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action

    Daunomycin (NSC-82151) is an antibiotic isolated from cultures of Streptomyces peucetius (DiMarco et al. 1963; DiMarco et al., 1964b). While weakly active against s...

    A. Di Marco, F. Arcamone, F. Zunino in Mechanism of Action of Antimicrobial and A… (1975)

  7. No Access

    Article

    Influence of some antitumor antibiotics on viral neoplasia

    P. Chandra, A. Di Marco, F. Zunino, A. M. Casazza, D. Gericke… in Naturwissenschaften (1972)

  8. No Access

    Chapter and Conference Paper

    Structure and Physicochemical Properties of Adriamycin (Doxorubicin)

    Adriamycin (synonym doxorubicin) is a glycoside antibiotic whose structure and stereochemistry are represented in Fig. 1 (formula I). It consists of the tetracyclic quinoid aglycone adriamycinone (14-hydroxyda...

    F. Arcamone, G. Cassinelli, G. Franceschi… in International Symposium on Adriamycin (1972)

  9. No Access

    Article

    Studies concerning the biogenesis of natural derivatives of lysergic acid

    Dall'esame della incorporazione di possibili precursori negli alcaloidi prodotti daC. paspali eC. purpurea risulta che non vi è una diretta correlazione fra la biogenesi delle catene laterali della ergometrina e ...

    A. Minghetti, F. Arcamone in Experientia (1969)

  10. No Access

    Article

    New carotenoids fromStreptomyces mediolani n. sp.

    Dal micelio diStreptomyces mediolani n. sp., coltivato in condizioni aereate e sommerse, sono stati isolati isorenieratene e due nuovi carotenoidi fenolici. In base ai risultati della demolizione ossidativa sono ...

    F. Arcamone, B. Camerino, E. Cotta, G. Franceschi, A. Grein, S. Penco… in Experientia (1969)

  11. No Access

    Article

    Mannosidohydroxystreptomycin fromStreptomyces sp.

    Viene descritto l'isolamento e lo studio chimico della mannosidoossistreptomicina, presente, insieme con ossistreptomicina, streptidina e toiocamicina, nelle colture delloStreptomyces 86. Il nuovo antibiotico ed ...

    F. Arcamone, G. Cassinelli, G. d'Amico, P. Orezzi in Experientia (1968)

  12. No Access

    Article

    Structure and Synthesis of Distamycin A

    DISTAMYCIN, a mixture of antibiotic substances exhibiting predominantly antifungal activity, was obtained by submerged fermentation and butanol extraction of the mycelial mass of a Streptomyces sp. An amorphous p...

    F. ARCAMONE, S. PENCO, P. OREZZI, V. NICOLELLA, ANNAMARIA PIRELLI in Nature (1964)

  13. No Access

    Article

    Formation of 2,3-Dihydroxybenzoic Acid in Fermentation Liquors during the Submerged Culture Production of Lysergic Acid α-Hydroxyethylamide by Claviceps paspali Stevens and Hall

    A STRAIN of Claviceps paspali Stevens and Hall has previously been shown to be capable of producing lysergic acid α-hydroxyethylamide in submerged fermentation1,2. Examination of chromatograms (solvent n-butanol/...

    F. ARCAMONE, E. B. CHAIN, A. FERRETTI, P. PENNELLA in Nature (1961)

  14. No Access

    Article

    Production of Lysergic Acid Derivatives by a Strain of Claviceps paspali Stevens and Hall in Submerged Culture

    A STRAIN of Claviceps paspali Stevens and Hall isolated from the grass Paspalum distichum L. found growing on a hill in the neighbourhood of Rome was found, after propagation on a rye embryo grown on agar1, to be...

    F. ARCAMONE, C. BONINO, E. B. CHAIN, A. FERRETTI, P. PENNELLA, A. TONOLO… in Nature (1960)