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Article
Loss of heterozygosity on chromosome 6q14–q24 is associated with poor outcome in children and adolescents with T-cell lymphoblastic lymphoma
Deletions of chromosome 6q have been reported in several hematological malignancies, but data are not conclusive regarding their biological and prognostic impact. Therefore, we focused on pediatric patients di...
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Article
Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study
This study was initiated to assess the quantitative impact of patient anthropometrics and dihydropyrimidine dehydrogenase (DPYD) mutations on the pharmacokinetics (PK) of 5-fluorouracil (5FU) and to explore limit...
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Article
Subjective body vertical: a promising diagnostic tool in idiopathic normal pressure hydrocephalus?
Postural instability is a frequent symptom of patients with idiopathic normal pressure hydrocephalus (iNPH), and might be due to the misperception of body verticality. The objective of this study was to assess...
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Article
Open AccessAcute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects
Lysergic acid diethylamide (LSD) induces profound changes in various mental domains, including perception, self-awareness and emotions. We used functional magnetic resonance imaging (fMRI) to investigate the a...
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Article
Off-label-Biologikatherapie bei Patienten mit Großgefäßvaskulitiden und/oder Polymyalgia rheumatica
Retrospektive Erfassung und Evaluation der klinischen Wirksamkeit und Sicherheit von Off-label-Biologikatherapien bei Patienten mit Großgefäßvaskulitiden und/oder Polymyalgia rheumatica im klinischen Alltag in...