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  1. No Access

    Article

    Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study

    This study was initiated to assess the quantitative impact of patient anthropometrics and dihydropyrimidine dehydrogenase (DPYD) mutations on the pharmacokinetics (PK) of 5-fluorouracil (5FU) and to explore limit...

    F. Mueller, B. Büchel, D. Köberle, S. Schürch… in Cancer Chemotherapy and Pharmacology (2013)

  2. Article

    Open Access

    Elevated preoperative CEA is associated with worse survival in stage I–III rectal cancer patients

    The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients.

    I Tarantino, R Warschkow, M Worni, K Merati-Kashani, D Köberle… in British Journal of Cancer (2012)

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  3. No Access

    Article

    Procollagen type I N-propeptide is a predictor of skeletal morbidity in patients with malignant osteolytic bone disease on bisphosphonates

    There is an urgent need for individualized treatment of malignant bone disease (MBD), as the clinical benefit from bone-targeted therapies is moderate. We assessed the predictive value of the bone formation ma...

    M. Joerger, A. Templeton, D. Köberle, H. Engler… in Cancer Chemotherapy and Pharmacology (2011)