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Article
Open AccessThe effects of glycemic index on prostate cancer progression in a xenograft mouse model
Previously, we found low-carbohydrate diets slowed prostate cancer (PC) growth and increased survival vs. a Western diet in mice, by inhibiting the insulin/IGF-1 axis. Thus, we tested whether modifying carbohy...
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Article
Open AccessHeat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival
There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this m...
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Article
Open AccessMESH1 knockdown triggers proliferation arrest through TAZ repression
All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-co** mechanism is the stringent response triggered by the accumulation o...
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Article
Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer
Some, but not all, epidemiologic evidence supports a role for cholesterol, the precursor for steroid hormone synthesis, in prostate cancer. Using a PTEN-null transgenic mouse model of prostate cancer, we teste...
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Article
Enhanced malignant tumorigenesis in Cdk4 transgenic mice
In a previous study, we reported that overexpression of cyclin-dependent kinase-4 (CDK4) in mouse epidermis results in epidermal hyperplasia, hypertrophy and severe dermal fibrosis. In this study, we have inve...
