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  1. No Access

    Article

    An allelic series of miR-17∼92–mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron

    Andrea Ventura and colleagues characterize an allelic series of genetically engineered mice harboring targeted deletions of individual members of the miR-17~92 cluster. They find evidence of functional coopera...

    Yoon-Chi Han, Joana A Vidigal, ** Mu, Evelyn Yao, Irtisha Singh… in Nature Genetics (2015)

  2. No Access

    Article

    Germline deletion of the miR-17∼92 cluster causes skeletal and growth defects in humans

    Andrea Ventura and colleagues report germline hemizygous deletions in the miR-17~92 cluster in individuals with features overlap** Feingold syndrome. Mice with targeted deletions in miR17~92 also display gro...

    Loïc de Pontual, Evelyn Yao, Patrick Callier, Laurence Faivre… in Nature Genetics (2011)

  3. No Access

    Article

    A non-genetic route to aneuploidy in human cancers

    Aneploidy is frequently observed in cancer. It is now shown that aneploidy can arise by entosis, the process of live cell internalisation by a neighbouring cell. The internalised cell can interfere with host c...

    Matej Krajcovic, Nicole B. Johnson, Qiang Sun, Guillaume Normand… in Nature Cell Biology (2011)