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Meningeal Multipotent Cells: A Hidden Target for CNS Repair?
Traditionally, the primary role of the meninges is thought to be structural, i.e., to act as a surrounding membrane that contains and cushions the brain with cerebrospinal fluid. During development, the mening...
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Article
Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic...
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Open AccessDiscovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion
The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective beh...
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The state of the art in stem cell biology and regenerative medicine: the end of the beginning
With translational stem cell biology and Regenerative Medicine (the field to which the former gave rise) now over a quarter century old, it is time to take stock of where we have been and where we are going. T...
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Modeling Complex Neurological Diseases with Stem Cells: A Study of Bipolar Disorder
The pathogenesis of bipolar disorder (BPD) is unknown. Using human-induced pluripotent stem cells (hiPSCs) to unravel pathological mechanisms in polygenic diseases is challenging, with few successful studies t...
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Multimodal Neural Stem Cell Research Protocols for Experimental Spinal Cord Injuries
Human neural stem cells (hNSCs) have been the focus in basic science and translational research as well as in investigative clinical applications. Therefore, the capability to perform reliable derivation, effe...
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Open AccessHuman neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury
Clinically, a good deal of injury from stroke results from ischemic-reperfusion. There is a loss of cerebral parenchyma and its associated cells, disruption of neuronal connections, compromise of the blood-bra...
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Reparative effects of neural stem cells in neonatal rats with hypoxic–ischemic injury are not influenced by host sex
Gender is increasingly recognized as an important influence on brain development, disease susceptibility, and response to pharmacologic/rehabilitative treatments. In regenerative medicine, it remains entirely ...
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Open AccessSpecial feature on stem cells: current research and future prospects
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Open AccessImplications and limitations of cellular reprogramming for psychiatric drug development
Human-induced pluripotent stem cells (hiPSCs) derived from somatic cells of patients have opened possibilities for in vitro modeling of the physiology of neural (and other) cells in psychiatric disease states. Is...
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Open AccessDeriving dopaminergic neurons for clinical use. A practical approach
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective in...
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Combined Total Proteomic and Phosphoproteomic Analysis of Human Pluripotent Stem Cells
Despite advances in understanding pluripotency through traditional cell biology and gene expression profiling, the signaling networks responsible for maintenance of pluripotency and lineage-specific differenti...
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Growth Dynamics of Fetal Human Neural Stem Cells
Human neural stem cells (hNSC) are useful for understanding neurogenesis, migration, other events in neural development, drug screening of developmental and disease targets, and potential neurological disease ...
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Three-dimensional scaffolding to investigate neuronal derivatives of human embryonic stem cells
Access to unlimited numbers of live human neurons derived from stem cells offers unique opportunities for in vitro modeling of neural development, disease-related cellular phenotypes, and drug testing and discove...
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Phosphoproteomic Analysis: An Emerging Role in Deciphering Cellular Signaling in Human Embryonic Stem Cells and Their Differentiated Derivatives
Cellular signaling is largely controlled by protein phosphorylation. This post-translational modification (PTM) has been extensively analyzed when examining one or a few protein phosphorylation events that eff...
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Open AccessNeurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption
Regulated neurotransmitter actions in the mammalian central nervous system determine brain function and control peripheral organs and behavior. Although drug-seeking behaviors, including alcohol consumption, d...
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Reply to “On the origin of glioneural neoplasms after neural cell transplantation”
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Article
The transcriptional network for mesenchymal transformation of brain tumours
The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of...
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Chapter
Functional Multipotency of Neural Stem Cells and Its Therapeutic Implications
In this review, we propose an updated concept of the neural stem cell (NSC). New data of our own and others suggest that the field’s conventional view which has touched principally on the essential multipotenc...
