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Article
Open AccessBIRC5 expression by race, age and clinical factors in breast cancer patients
Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target. However, BIRC5 has not been well studied among racially diverse population...
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Article
Open AccessReproducibility and intratumoral heterogeneity of the PAM50 breast cancer assay
The PAM50 assay is used routinely in clinical practice to determine breast cancer prognosis and management; however, research assessing how technical variation and intratumoral heterogeneity contribute to misc...
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Article
Racial differences in breast cancer outcomes by hepatocyte growth factor pathway expression
Black women have a 40% increased risk of breast cancer-related mortality. These outcome disparities may reflect differences in tumor pathways and a lack of targetable therapies for specific subtypes that are m...
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Article
Open AccessHepatocyte growth factor pathway expression in breast cancer by race and subtype
African American women have the highest risk of breast cancer mortality compared to other racial groups. Differences in tumor characteristics have been implicated as a possible cause; however, the tumor microe...
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Article
Open AccessBimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications
Female breast cancer demonstrates bimodal age frequency distribution patterns at diagnosis, interpretable as two main etiologic subtypes or grou**s of tumors with shared risk factors. While RNA-based methods...
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Article
Open AccessIntra-individual Gene Expression Variability of Histologically Normal Breast Tissue
Several studies have sought to identify novel transcriptional biomarkers in normal breast or breast microenvironment to predict tumor risk and prognosis. However, systematic efforts to evaluate intra-individua...
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Article
Open AccessFrequency of breast cancer subtypes among African American women in the AMBER consortium
Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional ma...
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Article
Open AccessRace-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study
We examined racial differences in the expression of eight genes and their associations with risk of recurrence among 478 white and 495 black women who participated in the Carolina Breast Cancer Study Phase 3.
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Article
Open AccessPuberty-specific promotion of mammary tumorigenesis by a high animal fat diet
Increased animal fat consumption is associated with increased premenopausal breast cancer risk in normal weight, but not overweight, women. This agrees with our previous findings in obesity-resistant BALB/c mi...
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Article
Race-associated biological differences among Luminal A breast tumors
African-American (AA) women have higher breast cancer-specific mortality rates. A higher prevalence of the worse outcome Basal-like breast cancer subtype contributes to this, but AA women also have higher mort...
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Article
Body mass index associated with genome-wide methylation in breast tissue
Gene expression studies indicate that body mass index (BMI) is associated with molecular pathways involved in inflammation, insulin-like growth factor activation, and other carcinogenic processes in breast tis...
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Article
Open AccessPubertal high fat diet: effects on mammary cancer development
Epidemiological studies linking dietary fat intake and obesity to breast cancer risk have produced inconsistent results. This may be due to the difficulty of dissociating fat intake from obesity, and/or the la...
