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Article
Open AccessDynamic molecular changes during the first week of human life follow a robust developmental trajectory
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteo...
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Article
Open AccessHigh-throughput detection of RNA processing in bacteria
Understanding the RNA processing of an organism’s transcriptome is an essential but challenging step in understanding its biology. Here we investigate with unprecedented detail the transcriptome of Pseudomonas ae...
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Article
Open AccessExploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis
Chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. There are, however, limited in vitro models to study the role of host genetics in th...
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Article
The immunology of host defence peptides: beyond antimicrobial activity
Host defence peptides (HDPs) display substantial immunomodulatory properties in vitro and in vivo, and these features are becoming increasingly appreciated in ...
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Article
NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data
This protocol describes NetworkAnalyst, a web-based tool for performing network analysis and visualization from gene lists and meta-analysis of gene expression datasets, and for displaying results as protein-p...
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Article
Open AccessESTs from the microsporidian Edhazardia aedis
Microsporidia are a group of parasites related to fungi that infect a wide variety of animals and have gained recognition from the medical community in the past 20 years due to their ability to infect immuno-c...
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Article
Open AccessStripped-down DNA repair in a highly reduced parasite
Encephalitozoon cuniculi is a member of a distinctive group of single-celled parasitic eukaryotes called microsporidia, which are closely related to fungi. Some of these organisms, including E. cuniculi, also hav...
