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Article
Open AccessSelf-organized formation of develo** appendages from murine pluripotent stem cells
Limb development starts with the formation of limb buds (LBs), which consist of tissues from two different germ layers; the lateral plate mesoderm-derived mesenchyme and ectoderm-derived surface epithelium. He...
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Article
Open AccessSelf-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism
The neuroectoderm is patterned along a rostral-caudal axis in response to localized factors in the embryo, but exactly how these factors act as positional information for this patterning is not yet fully under...
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Article
IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro
Insulin-like growth factors (IGFs) are involved in growth and tissue development, including diseases such as type-2 diabetes and cancers. However, their roles in lineage specification, especially in early mamm...
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Article
Open AccessActivation of Wnt/ß-catenin signaling in ESC promotes rostral forebrain differentiation in vitro
Wnt/ß-catenin signaling is crucial for maintenance of pluripotent state of embryonic stem cell (ESC). However, it is unclear how Wnt/ß-catenin signaling affects the differentiation ability of ESC, especially w...
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Article
Self-organizing optic-cup morphogenesis in three-dimensional culture
Balanced organogenesis requires the orchestration of multiple cellular interactions to create the collective cell behaviours that progressively shape develo** tissues. It is currently unclear how individual,...
