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  1. No Access

    Chapter

    Functions, Biogenesis and Pathology of Peroxisomes in Man

    Peroxisomes (microbodies; microperoxisomes), were first described morphologically by Rhodin (1) in 1954 and characterized biochemically by De Duve and coworkers (2) in the early 1960’s. They are defined as int...

    Erik A. C. Wiemer, Stanley Brul, Abraham Bout… in Organelles in Eukaryotic Cells (1989)

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    Article

    Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: An evolutionary scenario of subcellular compartmentation in Kinetoplastida

    In Trypanoplasma borelli, a representative of the Bodonina within the Kinetoplastida, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity was detected in both the cytosol and glycosomes. This situation is s...

    Erik A. C. Wiemer, Véronique Hannaert… in Journal of Molecular Evolution (1995)

  3. Article

    Open Access

    Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest

    Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for spe...

    Marijn T. M. van Jaarsveld, Difan Deng, Diana Ordoñez-Rueda, Malte Paulsen… in Oncogenesis (2020)

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  4. Article

    Open Access

    Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts

    Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down excessive osteoclast numbers, and thus ...

    Ruobing Wang, Yan Yang, Zhongyin Zhang, Na Zhao, Erik A. C. Wiemer… in Cell Death & Disease (2023)

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