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Article
Open AccessMajor vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts
Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down excessive osteoclast numbers, and thus ...
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Article
Open AccessCell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for spe...
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Article
Open AccessDeregulated microRNAs in neurofibromatosis type 1 derived malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNST) are aggressive cancers that occur spontaneously (sporadic MPNST) or from benign plexiform neurofibromas in neurofibromatosis type 1 (NF1) patients. MPNSTs metas...
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Article
Open AccessUncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell dissemination. Here, we apply an imaging-based RNA...
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Article
Open AccessMajor vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
Macrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and atherogenesis. However, the underlying regulatory mechanisms remain incompletely understood. Here, we identify major ...
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Article
Open AccessMiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells
Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cell...
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Article
Open AccessmiR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway
Drug resistance hampers the efficient treatment of malignancies, including advanced stage ovarian cancer, which has a 5-year survival rate of only 30 %. The molecular processes underlying resistance have been ...
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Article
Open AccessRelationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence
Circadian rhythms may influence the pharmacokinetics of drugs. This study aimed to elucidate whether the pharmacokinetics of the orally administered drug sunitinib are subject to circadian variation.
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Article
Open AccessCircadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients
The anti-estrogen tamoxifen is characterized by a large variability in response, partly due to pharmacokinetic differences. We examined circadian variation in tamoxifen pharmacokinetics in mice and breast canc...
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Article
Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen
Tamoxifen is a largely inactive pro-drug, requiring metabolism into its most important metabolite endoxifen. Since the cytochrome P450 (CYP) 2D6 enzyme is primarily involved in this metabolism, genetic polymor...
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Article
Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer
Epithelial to mesenchymal transition (EMT) is typically defined by the acquisition of a spindle cell morphology in combination with loss of E-cadherin and upregulation of mesenchymal markers. However, by study...
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Article
Stressed tumor cell, chemosensitized cancer
miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this app...
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Article
Open AccessIncreasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study
Response to anticancer therapy is believed to be directly related to the concentration of the anticancer drug in the tumor itself. Assessment of intra-tumor drug pharmacokinetics can be helpful to gain more in...
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Article
Open AccessEffects of methimazole on the elimination of irinotecan
To study the possible pharmacokinetic and pharmacodynamic interactions between irinotecan and methimazole.
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Role of MicroRNAs in Anti-cancer Drug Resistance
MicroRNAs (miRNAs) are key regulators of various cellular and developmental processes, and are closely linked to the pathogenesis of a number of diseases including cancer. In recent years, several miRNAs have ...
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Article
Open AccessMicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation
MicroRNAs (miRNAs) are non-protein coding molecules with important regulatory functions; many have tissue-specific expression patterns. Their very small size in principle makes them less prone to degradation p...
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Article
Open AccessApplication of prolonged microdialysis sampling in carboplatin-treated cancer patients
To better understand the mechanisms underlying (in)sensitivity of tumors to anticancer drugs, assessing intra-tumor drug pharmacokinetics (PKs) could be important. We explored the feasibility of microdialysis ...
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Article
Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: An evolutionary scenario of subcellular compartmentation in Kinetoplastida
In Trypanoplasma borelli, a representative of the Bodonina within the Kinetoplastida, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity was detected in both the cytosol and glycosomes. This situation is s...
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Functions, Biogenesis and Pathology of Peroxisomes in Man
Peroxisomes (microbodies; microperoxisomes), were first described morphologically by Rhodin (1) in 1954 and characterized biochemically by De Duve and coworkers (2) in the early 1960’s. They are defined as int...
