-
Article
Open AccessMajor vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts
Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down excessive osteoclast numbers, and thus ...
-
Article
Open AccessCell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest
Cancer is a life-threatening disease that affects one in three people. Although most cases are sporadic, cancer risk can be increased by genetic factors. It remains unknown why certain genes predispose for spe...
-
Article
Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: An evolutionary scenario of subcellular compartmentation in Kinetoplastida
In Trypanoplasma borelli, a representative of the Bodonina within the Kinetoplastida, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity was detected in both the cytosol and glycosomes. This situation is s...
-
Chapter
Functions, Biogenesis and Pathology of Peroxisomes in Man
Peroxisomes (microbodies; microperoxisomes), were first described morphologically by Rhodin (1) in 1954 and characterized biochemically by De Duve and coworkers (2) in the early 1960’s. They are defined as int...