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  1. Article

    Open Access

    Inpatient-level care at home delivered by virtual wards and hospital at home: a systematic review and meta-analysis of complex interventions and their components

    Technology-enabled inpatient-level care at home services, such as virtual wards and hospital at home, are being rapidly implemented. This is the first systematic review to link the components of these service ...

    Chunhu Shi, Jo Dumville, Fernando Rubinstein, Gill Norman, Akbar Ullah… in BMC Medicine (2024)

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  2. No Access

    Article

    Quality improvement and delirium

    An overview of the principles of quality improvement and summary of these as they apply to the clinical field of delirium.

    Emma R. L. C. Vardy, Rebecca E. Thompson in European Geriatric Medicine (2020)

  3. Article

    Open Access

    Plasma metals as potential biomarkers in dementia: a case–control study in patients with sporadic Alzheimer’s disease

    Sporadic Alzheimer’s disease (AD) is a neurodegenerative disorder that causes the most prevalent form of age-related dementia but its pathogenesis remains obscure. Altered regulation of metals, particularly pa...

    **gshu Xu, Stephanie J. Church, Stefano Patassini, Paul Begley… in BioMetals (2018)

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  4. Article

    Open Access

    Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia

    Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer’s disease (AD). Here we sought to further elucidate the processes that cause neurodegeneration in AD by measuring levels of me...

    **gshu Xu, Paul Begley, Stephanie J. Church, Stefano Patassini… in Scientific Reports (2016)

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  5. No Access

    Article

    Review of delirium in patients with Parkinson’s disease

    Parkinson’s disease (PD) is common and has a number of associated neuropsychiatric disturbances. Of these, delirium has historically been under-recognised. Delirium is an acute disturbance of attention and awa...

    Emma R. L. C. Vardy, Andrew Teodorczuk, Alison J. Yarnall in Journal of Neurology (2015)

  6. No Access

    Article

    Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

    Julie Williams, Michael Owen and colleagues report staged follow-up and meta-analyses of genome-wide association studies for Alzheimer's disease from the GERAD+ consortium. They identify common variants at ABCA7 ...

    Paul Hollingworth, Denise Harold, Rebecca Sims, Amy Gerrish… in Nature Genetics (2011)

  7. No Access

    Chapter

    Secretases as Pharmacological Targets in Alzheimer's Disease

    Alzheimer’s disease (AD) is the major neurodegenerative disease of the aging brain and, whereas the underlying pathology remains extremely complex and poorly understood, poses an ever-expanding burden on healt...

    Nigel M. Hooper, Emma R. L. C. Vardy in Pharmacological Mechanisms in Alzheimer's … (2007)