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  1. No Access

    Article

    Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factors

    Genetic screens using pooled CRISPR-based approaches are scalable and inexpensive, but restricted to standard readouts, including survival, proliferation and sortable markers. However, many biologically releva...

    Emily C. Wheeler, Anthony Q. Vu, Jaclyn M. Einstein, Matthew DiSalvo… in Nature Methods (2020)

  2. Article

    Open Access

    Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins

    A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP) methods enable map** RBP targets ...

    Eric L. Van Nostrand, Gabriel A. Pratt, Brian A. Yee, Emily C. Wheeler… in Genome Biology (2020)

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    Article

    RNA-binding protein CPEB1 remodels host and viral RNA landscapes

    The RNA-binding protein CPEB1 drives post-transcriptional changes in the host transcriptome and poly(A)-tail lengthening of viral RNAs, processes essential for productive HCMV infection.

    Ranjan Batra, Thomas J Stark, Alex E. Clark… in Nature Structural & Molecular Biology (2016)