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  1. No Access

    Article

    Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects

    Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET) DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of oxidized 5mC. Existing single-cell bisulf...

    Emily B. Fabyanic, Peng Hu, Qi Qiu, Kiara N. Berríos… in Nature Biotechnology (2024)

  2. No Access

    Article

    Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase

    A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples.

    Emily K Schutsky, Jamie E DeNizio, Peng Hu, Monica Yun Liu… in Nature Biotechnology (2018)