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Article
Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase
A bisulfite-free sequencing method yields high-confidence 5hmC profiles in low-input samples.
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Article
Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects
Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET) DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of oxidized 5mC. Existing single-cell bisulf...