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  1. Article

    Germinal centre-driven maturation of B cell response to mRNA vaccination

    Germinal centres (GC) are lymphoid structures in which B cells acquire affinity-enhancing somatic hypermutations (SHM), with surviving clones differentiating into memory B cells (MBCs) and long-lived bone marr...

    Wooseob Kim, Julian Q. Zhou, Stephen C. Horvath, Aaron J. Schmitz… in Nature (2022)

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  2. Article

    SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

    SARS-CoV-2 mRNA-based vaccines are about 95% effective in preventing COVID-191–5. The dynamics of antibody-secreting plasmablasts and germinal centre B cells induced by these vaccines in humans remain unclear. He...

    Jackson S. Turner, Jane A. O’Halloran, Elizaveta Kalaidina, Wooseob Kim… in Nature (2021)

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  3. Article

    SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

    Long-lived bone marrow plasma cells (BMPCs) are a persistent and essential source of protective antibodies1–7. Individuals who have recovered from COVID-19 have a substantially lower risk of reinfection with SARS...

    Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss… in Nature (2021)

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