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  1. No Access

    Article

    Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis

    The BCL-2 family of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1, can mediate survival of some types of cancer. DT2216 is a PROteolysis-TArgeting Chimera (PROTAC) that degrades BCL-XL specifically and is i...

    Arunima Jaiswal, Aruna Jaiswal… in Cancer Chemotherapy and Pharmacology (2023)

  2. Article

    Open Access

    Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

    Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have so...

    Gayathri Srinivasan, Gurjit Singh Sidhu… in Cancer Chemotherapy and Pharmacology (2017)

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    Article

    Cytotoxic activity of the titanium alkoxide (OPy)2Ti(4AP)2 against cancer colony forming cells

    A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colon...

    Elizabeth A. Williamson, Timothy J. Boyle, Rebecca Raymond… in Investigational New Drugs (2012)

  4. No Access

    Article

    Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

    A pharmacological-based global screen for epigenetically silenced tumor suppressor genes was performed in MCF-7 and MDA-MB-231 breast cancer cells. Eighty-one genes in MCF-7 cells and 131 in MDA-MB-231 cells w...

    Ido Wolf, Shikha Bose, Julian C. Desmond… in Breast Cancer Research and Treatment (2007)

  5. No Access

    Article

    BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1

    The p27Kip1 is a member of the universal cyclin-dependent kinase inhibitor family. Previously, immunochemical analysis of a series of breast cancer cell lines demonstrated a correlation between the expression of ...

    Elizabeth A Williamson, Farnaz Dadmanesh, H Phillip Koeffler in Oncogene (2002)