6 Result(s)

Article

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target degradation through the recruitment of the CCR4-NOT deadenylase complex and are implicated in the prevention of autoimmunity. Roqui...

Annamaria Sgromo, Tobias Raisch, Praveen Bawankar… in Nature Communications (2017)

Article

Erratum: An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay

Nat. Struct. Mol. Biol. 21, 599–608 (2014); published online 1 June 2014; corrected after print 22 August 2014. In the version of this article initially published, a rotation sign was mistakenly introduced bet...

Stefanie Jonas, Mary Christie, Daniel Peter… in Nature Structural & Molecular Biology (2014)

Article

4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation

eIF4E-binding proteins (4E-BPs) are a widespread class of translational regulators that share a canonical (C) eIF4E-binding motif (4E-BM) with eIF4G. Consequently, 4E-BPs compete with eIF4G for binding to the ...

Cátia Igreja, Daniel Peter, Catrin Weiler, Elisa Izaurralde in Nature Communications (2014)

Article

Freedom versus constraint in protein function

Elisa Izaurralde in Nature Reviews Molecular Cell Biology (2009)

Article

The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold

Multimeric protein complexes have a role in many cellular pathways and are highly interconnected with various other proteins. The characterization of their domain composition and organization provides useful i...

Francesca D Ciccarelli, Elisa Izaurralde, Peer Bork in BMC Bioinformatics (2003)

Article

Structure and dynamics of the post-transcriptional mRNA-processing machinery

A report on the 'RNA processsing' and 'Nuclear Import and Export' minisymposia at the first meeting of the European Life Scientist Organization (ELSO), Geneva, 2-6 September, 2000.

Elisa Izaurralde in Genome Biology (2000)