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Article
Open AccessT cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 and how they are subsequently...
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Article
Open AccessGeneration of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression
Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety and feasibility of a T regulatory type 1 (Tr1)-ce...
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Protocol
Expanding Human T Regulatory Cells with the mTOR-Inhibitor Rapamycin
CD4+CD25+FOXP3+ T regulatory (Treg) cells are pivotal for the induction and maintenance of peripheral tolerance in both mice and humans. The possibility to use Treg cells for the treatment of T-cell-mediated dise...
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Article
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
Following the identification of the C-C chemokines RANTES, MIP-1α and MIP-1β as major human immunodeficiency virus (HIV)-suppressive factors produced by CD8+ T cells1, several chemokine receptors were found to se...
