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Article
Open AccessMirror proteorhodopsins
Proteorhodopsins (PRs), bacterial light-driven outward proton pumps comprise the first discovered and largest family of rhodopsins, they play a significant role in life on the Earth. A big remaining mystery wa...
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Article
Open AccessStructural insights into thrombolytic activity of destabilase from medicinal leech
Destabilase from the medical leech Hirudo medicinalis belongs to the family of i-type lysozymes. It has two different enzymatic activities: microbial cell walls destruction (muramidase activity), and dissolution ...
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Article
Open AccessStructural basis for receptor selectivity and inverse agonism in S1P5 receptors
The bioactive lysophospholipid sphingosine-1-phosphate (S1P) acts via five different subtypes of S1P receptors (S1PRs) - S1P1-5. S1P5 is predominantly expressed in nervous and immune systems, regulating the egres...
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Article
Open AccessAuthor Correction: Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs
A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759-w
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Article
Open AccessSmall-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs
Structural studies of challenging targets such as G protein-coupled receptors (GPCRs) have accelerated during the last several years due to the development of new approaches, including small-wedge and serial c...
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Article
Open AccessMolecular mechanism of light-driven sodium pum**
The light-driven sodium-pum** rhodopsin KR2 from Krokinobacter eikastus is the only non-proton cation active transporter with demonstrated potential for optogenetics. However, the existing structural data on KR...
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Article
Open AccessStructural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma ...
