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Article
Open AccessDifferential methylation analysis in neuropathologically confirmed dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation map** of cerebellar tissue from pathologically confirmed DLB cases and control...
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Article
Open AccessLearning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels
Precise, scalable, and quantitative evaluation of whole slide images is crucial in neuropathology. We release a deep learning model for rapid object detection and precise information on the identification, loc...
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Article
Open AccessOutcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"
The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The worksh...
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Reference Work Entry In depth
Induction and Patterning in the Telencephalon
Sitting at the front of the central nervous system (CNS), the telencephalon gives rise to many brain regions including the cerebral cortex – the seat of cognition, consciousness, and mind that uniquely defines...
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Living Reference Work Entry In depth
Induction and Patterning in the Telencephalon
Sitting at the front of the central nervous system (CNS), the telencephalon gives rise to many brain regions including the cerebral cortex – the seat of cognition, consciousness, and mind that uniquely defines...
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Article
Open AccessInfection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
Early evaluations of healthcare professional (HCP) COVID-19 risk occurred during insufficient personal protective equipment and disproportionate testing, contributing to perceptions of high patient-care relate...
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Article
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architect...
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Article
Open AccessAccurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC
Choroid plexus epithelial cells express high levels of transthyretin, produce cerebrospinal fluid and many of its proteins, and make up the blood-cerebrospinal fluid barrier. Choroid plexus epithelial cells ar...
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Article
Open AccessSystems healthcare: a holistic paradigm for tomorrow
Systems healthcare is a holistic approach to health premised on systems biology and medicine. The approach integrates data from molecules, cells, organs, the individual, families, communities, and the natural ...
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Article
Development and functions of the choroid plexus–cerebrospinal fluid system
The choroid plexus (ChP) is a secretory tissue found in each of the brain ventricles, the main function of which is to produce cerebrospinal fluid (CSF). Altho...
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Article
Effects of hematopoietic stem cell transplantation on acyl-CoA oxidase deficiency: a sibling comparison study
Acyl-CoA oxidase (ACOX1) deficiency is a rare disorder of peroxisomal very-long chain fatty acid oxidation. No reports detailing attempted treatment, longitudinal imaging, or neuropathology exist. We describe ...
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Article
Open AccessA hybrid microfluidic-vacuum device for direct interfacing with conventional cell culture methods
Microfluidics is an enabling technology with a number of advantages over traditional tissue culture methods when precise control of cellular microenvironment is required. However, there are a number of practic...
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Article
Mechanisms of cerebral cortical patterning in mice and humans
All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subs...
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Article
Proto-map** the areas of cerebral cortex: transcription factors make the grade
Two new studies demonstrate how the homeodomain genes Emx2 and Pax6 may work together to provide positional information to the develo** neocortex.
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Chapter and Conference Paper
The Myelination Cascade
The elaboration of myelin represents the culmination of a complex developmental interaction between neurons and glia. A variety of experiments with myelinating systems in vivo and in vitro are con...
