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Coronavirus surveillance of wildlife in the Lao People’s Democratic Republic detects viral RNA in rodents
Coronaviruses can become zoonotic, as in the case of COVID-19, and hunting, sale, and consumption of wild animals in Southeast Asia increases the risk for such incidents. We sampled and tested rodents (851) an...
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Article
CRAGE enables rapid activation of biosynthetic gene clusters in undomesticated bacteria
It is generally believed that exchange of secondary metabolite biosynthetic gene clusters (BGCs) among closely related bacteria is an important driver of BGC evolution and diversification. Applying this idea m...
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DNA of diverse adenoviruses detected in Cameroonian rodent and shrew species
Rodent adenoviruses are important models for human disease. In contrast to the over 70 adenovirus types isolated from humans, few rodent adenoviruses are known, despite the vast diversity of rodent species. PC...
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Article
Author Correction: The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses
In the version of this Article originally published, the bat species for 12 individuals were incorrectly identified in Supplementary Table 1 and 2. After resequencing the MT-CytB and MT-CO1 segments and reviewing...
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Correction: Author Correction: Rhizosphere microbiome structure alters to enable wilt resistance in tomato
Nat. Biotechnol.; 10.1038/nbt.4232; corrected online 23 October 2018 In the version of this article initially published online, the citations to Supplementary Figures 12a and 12b were interchanged in section “...
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Rhizosphere microbiome structure alters to enable wilt resistance in tomato
Tomato rhizosphere microbiome alterations that contribute to bacterial wilt resistance are detected using metagenomics.
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The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses
Here we describe the complete genome of a new ebolavirus, Bombali virus (BOMV) detected in free-tailed bats in Sierra Leone (little free-tailed (Chaerephon pumilus) and Angolan free-tailed (Mops condylurus)). The...
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Open AccessCritical Assessment of Metagenome Interpretation—a benchmark of metagenomics software
The Critical Assessment of Metagenome Interpretation (CAMI) community initiative presents results from its first challenge, a rigorous benchmarking of software for metagenome assembly, binning and taxonomic pr...
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The future of DNA sequencing
Eric D. Green, Edward M. Rubin and Maynard V. Olson speculate on the next forty years of the applications, from policing to data storage.
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Open AccessGene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane yield in sheep
Ruminants are important contributors to global methane emissions via microbial fermentation in their reticulo-rumens. This study is part of a larger program, characterising the rumen microbiomes of sheep which...
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Open AccessRumen metagenome and metatranscriptome analyses of low methane yield sheep reveals a Sharpea-enriched microbiome characterised by lactic acid formation and utilisation
Enteric fermentation by farmed ruminant animals is a major source of methane and constitutes the second largest anthropogenic contributor to global warming. Reducing methane emissions from ruminants is needed ...
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Open AccessGenome-wide compendium and functional assessment of in vivo heart enhancers
Whole-genome sequencing is identifying growing numbers of non-coding variants in human disease studies, but the lack of accurate functional annotations prevents their interpretation. We describe the genome-wid...
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Open AccessGlobal metagenomic survey reveals a new bacterial candidate phylum in geothermal springs
Analysis of the increasing wealth of metagenomic data collected from diverse environments can lead to the discovery of novel branches on the tree of life. Here we analyse 5.2 Tb of metagenomic data collected g...
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Open AccessInsights into the phylogeny and coding potential of microbial dark matter
Genome sequencing enhances our understanding of the biological world by providing blueprints for the evolutionary and functional diversity that shapes the biosphere. However, microbial genomes that are current...
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Large-scale discovery of enhancers from human heart tissue
Len Pennacchio, Axel Visel and colleagues use an epigenomic approach to identify a large number of candidate enhancers from human heart tissue. This work will facilitate further studies into the role of enhanc...
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Metagenomic analysis of a permafrost microbial community reveals a rapid response to thaw
Permafrost soil in the Arctic contains a huge reservoir of carbon. If the climate warms and the permafrost thaws, this carbon would become accessible to microbial degradation, releasing greenhouse gases in the...
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ChIP-Seq identification of weakly conserved heart enhancers
Len Pennacchio and colleagues used ChIP-Seq with the enhancer-associated protein p300 to identify 3,000 candidate cardiac transcriptional enhancers in embryonic mice at E11.5. Notably, most candidate heart enh...
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Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
It has been know for several years that genetic variations in a stretch of DNA on chromosome 9p21 are linked to the incidence of coronary artery disease. The nature of this link has remained unknown, not least...
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Open AccessA phylogeny-driven genomic encyclopaedia of Bacteria and Archaea
The bacterial and archaeal genomes that have been sequenced to date were chosen for sequencing based mainly on their physiology, which is fine but has resulted in a distinct phylogenetic bias. An alternative a...
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Genomic views of distant-acting enhancers
In contrast to protein-coding sequences, the significance of variation in non-coding DNA in human disease has been minimally explored. A great number of recent genome-wide association studies suggest that non-...
