63 Result(s)

Article

ChIP-seq accurately predicts tissue-specific activity of enhancers

A major yet unresolved quest in decoding the human genome is the identification of the regulatory sequences that control the spatial and temporal expression of genes. Distant-acting transcriptional enhancers a...

Axel Visel, Matthew J. Blow, Zirong Li, Tao Zhang, Jennifer A. Akiyama, Amy Holt… in Nature (2009)

Article

Genomics of cellulosic biofuels

The first wave of biofuels has had a significant impact on world energy markets. But there are major concerns about the knock-on effects on food prices. Hence a growing interest in 'cellulosic' feedstocks, suc...

Edward M. Rubin in Nature (2008)

Article

Ultraconservation identifies a small subset of extremely constrained developmental enhancers

Extended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional uniqueness. We used a transgenic mouse assay to compare th...

Axel Visel, Shyam Prabhakar, Jennifer A Akiyama, Malak Shoukry… in Nature Genetics (2008)

Article

Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite

Wood-feeding higher termites are a very successful group, important in facilitating carbon turnover in the environment. It is not the termites themselves that perform the key reactions that makes their lifesty...

Falk Warnecke, Peter Luginbühl, Natalia Ivanova, Majid Ghassemian… in Nature (2007)

Article

In vivo enhancer analysis of human conserved non-coding sequences

Identifying the non-coding DNA sequences that act at a distance to regulate patterns of gene expression is not a simple matter; one useful pointer is evolutionary sequence conservation. An in vivo analysis of 167...

Len A. Pennacchio, Nadav Ahituv, Alan M. Moses, Shyam Prabhakar… in Nature (2006)

Article

Symbiosis insights through metagenomic analysis of a microbial consortium

Symbioses between bacteria and eukaryotes are ubiquitous, yet our understanding of the interactions driving these associations is hampered by our inability to cultivate most host-associated microbes. Here we u...

Tanja Woyke, Hanno Teeling, Natalia N. Ivanova, Marcel Huntemann, Michael Richter… in Nature (2006)

Article

A distal enhancer and an ultraconserved exon are derived from a novel retroposon

Evidence from vertebrate genome sequences has shown that conserved noncoding regions significantly outnumber coding regions, and that these elements are mostly involved in gene regulation. The origins of these...

Gill Bejerano, Craig B. Lowe, Nadav Ahituv, Bryan King, Adam Siepel… in Nature (2006)

Article

Metagenomics: DNA sequencing of environmental samples

Article

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

The phenotype of Ter testicular germ cell tumour susceptibility gene was first described more than 30 years ago, but it has taken until now for the identity of the gene to be discovered. Ter is a mutation inducin...

Kirsten K. Youngren, Douglas Coveney, **aoning Peng, Chitralekha Bhattacharya… in Nature (2005)

Article

Comparative genomic analysis reveals a distant liver enhancer upstream of the COUP-TFII gene

COUP-TFII is a central nuclear hormone receptor that tightly regulates the expression of numerous target lipid metabolism genes in vertebrates. However, it remains unclear how COUP-TFII itself is transcriptionall...

Nadine Baroukh, Nadav Ahituv, Jessie Chang, Malak Shoukry, Veena Afzal… in Mammalian Genome (2005)

Article

The sequence and analysis of duplication-rich human chromosome 16

Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing ov...

Joel Martin, Cliff Han, Laurie A. Gordon, Astrid Terry, Shyam Prabhakar… in Nature (2004)

Article

Megabase deletions of gene deserts result in viable mice

The functional importance of the roughly 98% of mammalian genomes not corresponding to protein coding sequences remains largely undetermined¹. Here we show that some large-scale deletions of the non-coding DNA re...

Marcelo A. Nóbrega, Yiwen Zhu, Ingrid Plajzer-Frick, Veena Afzal, Edward M. Rubin in Nature (2004)

Article

Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs

The interaction between two genes, Agouti and Melanocortin-1 receptor (Mc1r), produces diverse pigment patterns in mammals by regulating the type, amount, and distribution pattern of the two pigm...

Julie A. Kerns, J. Newton, Tom G. Berryere, Edward M. Rubin… in Mammalian Genome (2004)

Article

The DNA sequence and comparative analysis of human chromosome 5

Chromosome 5 is one of the largest human chromosomes and contains numerous intrachromosomal duplications, yet it has one of the lowest gene densities. This is partially explained by numerous gene-poor regions ...

Jeremy Schmutz, Joel Martin, Astrid Terry, Olivier Couronne, Jane Grimwood… in Nature (2004)

Article

Comparative genomics at the vertebrate extremes