11 Result(s)

Article

Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response

Macroautophagy (hereafter autophagy) degrades and recycles intracellular components to sustain metabolism and survival during starvation. Host autophagy promotes tumor growth by providing essential tumor nutri...

Laura Poillet-Perez, Daniel W. Sharp, Yang Yang, Saurabh V. Laddha… in Nature Cancer (2020)

Article

Phase I neoadjuvant study of intravesical recombinant fowlpox-GM-CSF (rF-GM-CSF) or fowlpox-TRICOM (rF-TRICOM) in patients with bladder carcinoma

Intravesical BCG is a highly effective treatment for high-grade nonmuscle invasive bladder cancer and carcinoma in situ (CIS); however, for patients who are either resistant or become unresponsive to BCG thera...

Daniella E. Portal, Robert E. Weiss, Malgorzata Wojtowicz… in Cancer Gene Therapy (2020)

Article

Virotherapy clinical trials for regional disease: In situ immune modulation using recombinant poxvirus vectors

The ability of viruses to readily infect tumor cells both in vitro and in vivo has resulted in their study as antitumor agents through a variety of strategies. Replicating and conditionally replicating viruses an...

Michael J Mastrangelo, Edmund C Lattime in Cancer Gene Therapy (2002)

Chapter

Intralesional Vaccinia/GM-CSF Recombinant Virus in the Treatment of Metastatic Melanoma

Michael J. Mastrangelo, Henry C. Maguire, Edmund C. Lattime in Cancer Gene Therapy (2002)

Article

Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma

Seven immunocompetent, revaccinated patients with surgically incurable cutaneous melanoma underwent treatment of dermal and/or subcutaneous metastases with twice-weekly intratumoral injections of escalating do...

Michael J Mastrangelo, Henry C Maguire Jr., Laurence C Eisenlohr… in Cancer Gene Therapy (1999)

Chapter

Cellular vaccine therapies for cancer

The presence of functionally specific tumor-associated antigens was first convincingly demonstrated by Prehn and Main [1]. These investigators immunized syngeneic mice with a chemically induced sarcoma using a te...

Michael J. Mastrangelo, Takami Sato… in Biological and Hormonal Therapies of Cancer (1998)

Article

Expression of cytokine mRNA in human melanoma tissues

We have reported that patients with metastatic melanoma treated with an autologous, dinitrophenol-modified vaccine develop inflammatory responses at tumor sites. Histologically, these inflamed lesions are char...

Edmund C. Lattime, Michael J. Mastrangelo, Omar Bagasra… in Cancer Immunology, Immunotherapy (1995)

Article

Induction of TH1- and TH2-associated cytokine mRNA in mouse bladder following intravesical growth of the murine bladder tumor MB49 and BCG immunotherapy

Productive immunity to murine and human parasites is associated with the development of a type I T cell response (interferon-γ-producing) while type II responses (interleukin-4-producing) suppress the developm...

Kathleen M. McAveney, Leonard G. Gomella… in Cancer Immunology, Immunotherapy (1994)

Article

Natural cytotoxic (NC) activity: A multi-lineage system regulated by IL-2

The studies described in this report demonstrate that NC activity is the function of a number of distinct effector cell populations and not due to a single type of NC cell. While IL-2 was found to augment the ...

Edmund C. Lattime, Michael J. Bykowsky, Osias Stutman in Immunologic Research (1986)

Article

Natural cytotoxic activity: An introduction

Edmund C. Lattime in Immunologic Research (1986)