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  1. No Access

    Chapter

    Discoidin Domain Receptors in Cardiac Development

    Heart development is a complex process, involving temporally and spatially restricted morphogenic events that ultimately give rise to a multichambered heart. Discoidin domain receptors (DDRs) 1 and 2 are recep...

    David E. Justus, Adam Hoffman… in Discoidin Domain Receptors in Health and D… (2016)

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    Article

    Adaptive Changes in Cardiac Fibroblast Morphology and Collagen Organization as a Result of Mechanical Environment

    There is a growing body of work in the literature that demonstrates the significant differences between 2D versus 3D environments in cell morphologies, spatial organization, cell–ECM interactions, and cell sig...

    Sarah C. Baxter, Mary O. Morales, Edie C. Goldsmith in Cell Biochemistry and Biophysics (2008)

  3. No Access

    Chapter

    The Role of the Extracellular Matrix and Its Receptors in Modulating Cardiac Development

    Fundamental to the differentiation and morphogenesis of any organ is the interaction between its component cells and the extracellular matrix (ECM). In the early 1980s, the concept of dynamic reciprocity was i...

    Edie C. Goldsmith, Wayne Carver… in Formation of the Heart and Its Regulation (2001)