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Electron Spectroscopic Tomography of Specific Chromatin Domains
The eukaryotic genome is packaged within the nucleus as poly-nucleosome 10 nm chromatin fibres. The nucleosome core particle, the fundamental chromatin subunit, consists of a DNA molecule wrapped around a hist...
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Article
Elucidating chromatin and nuclear domain architecture with electron spectroscopic imaging
Electron microscopy has been the ‘gold standard’ of spatial resolution for studying the structure of the cell nucleus. Electron spectroscopic imaging (ESI) offers advantages over conventional transmission elec...
