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Article
Effect of grinding on the dehydration behavior of nedocromil sodium hydrates
Nedocromil sodium has a number of known hydrate states, a monohydrate, a trihydrate and a heptahemihydrate, including an amorphous state. Effect of grinding on the hydration states of nedocromil sodium crystal...
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Article
Mechanism of glass ampoule breakage prevention during the freeze-drying process of sodium thiopental lyophilization products on addition of sodium chloride
Glass ampoule breakage during the freeze-drying process was prevented by the addition of sodium chloride to the formulation of lyophilization products of sodium thiopental. In order to clarify the ampoule brea...
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Article
Application of microcalorimetry to the formulation study
Isothermal microcalorimetry was used to evaluate excipient compatibility of solid dosage form. Oxybutynin hydrochloride and cefaclor were used as model drugs for compatibility test with excipients. The calorim...
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Article
Application of XRD-DSC system to the optimization of manufacturing process for the freeze-dried pharmaceuticals
We have developed the vacuum dryer attached XRD-DSC system and monitored manufacturing process of freeze-dried pharmaceutical product. The aim of this study is to apply the XRD-DSC system for the preformulatio...
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Article
Estimation of physical stability of amorphous solid dispersion using differential scanning calorimetry
The physical stability of amorphous drug in solid dispersion was estimated using differential scanning calorimetry (DSC). Tolbutamide (TB) and flurbiprofen (FBP) were selected as insoluble drugs in water. Poly...
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Article
Complex Formation Between Erythritol and 4-hexylresorcinol
The interaction between erythritol and 4-hexylresorcinol during heating was investigated by thermal analysis, powder X-ray diffractometry and infrared spectroscopy. A phase diagram was constructed by measuring...