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19 Result(s)
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E. Sofic
Neurosciences
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Article
Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30
Low intracerebroventricular (icv) doses of streptozotocin (STZ) produce regionally specific brain neurochemical changes in rats that are similar to those found in the brain of patients with sporadic Alzheimer’...
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Article
Antioxidant capacity in rat brain after ICV treatment with streptozotocin and alloxan — a preliminary study
Intracerebroventricular (icv) administration of betacytotoxic drug streptozotocin (STZ) produces long-term and progressive cognitive deficits in rats, as well as deficits in cerebral glucose and energy metabol...
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Article
The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats
We investigated the effects of exogenous melatonin on the thyrocytes morphology in gamma-irradiated rats under condition where the pineal gland, as a main physiological source of endogenous melatonin, was remo...
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Article
Antioxidant capacity of the neurohormone melatonin
The aim of this study was to elucidate the antioxidant behaviour of melatonin (M) and determine its activity–structure relationship. M or 5-metoxy-N acetyltriptamine is a neurohormone secreted by the pineal gl...
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Article
Serum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy
The role of free radicals (FR) in the pathogenesis and in the progression of many diseases has been often discussed, but not widely investigated. However, the total antioxidant capacity in the serum seems to ...
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Article
Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases
The antioxidant and pro-oxidant capacity of catecholamines (CA) and related compounds were analyzed using the oxygen radical absorbance capacity (ORAC) assay. In the assay 2,2′-azobis (2-amidino-propane) dihy...
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Article
Depression in Parkinson's disease: biogenic amines in CSF of “de novo” patients
Introduction. Etiology of depression in Parkinsons disease (PD) is associated with serotonergic dysfunction. Previous studies, supporting this hypothesis, were performed on patients treated with antiparkinsonian...
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Chapter and Conference Paper
Brofaromine (CGP 11 305 A): estimation of plasma concentrations by a biologic technique as compared to liquid chromatography
In an open clinical trial 13 depressives significantly improved under the reversible and selective type-A monoamine oxidase (MAO) inhibitor brofaromine. The inhibitory potency of deproteinated plasma on a crud...
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Chapter and Conference Paper
Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder
N = 53 inpatients with major depressive disorder have been treated with the reversible, selective MAO-A-inhibitors moclobemide (double-blind versus maprotiline) and brofaromine (open study), respectively. Clin...
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Chapter and Conference Paper
Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms
To test whether changes in basic biochemical membrane constituents were reflected in membrane fluidity measurements, protein, total lipids, triglycerides, lecithine, cholesterol and alkaline phosphatase were d...
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Chapter
Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences
Parkinson’s disease (PD) is characterized by a clear rank order with respect to neuropathological findings. Both substantia nigra (SN) and locus coeruleus (LC) are severely damaged, whilst nucleus raphe dorsal...
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Chapter and Conference Paper
Urinary dopamine sulfate: regulations and significance in neurological disorders
Dopamine-3-O-sulfate (DA-3-O-S) and dopamine-4-O-sulfate (DA-4-O-S) are important end products of L-dopa metabolism. Therefore they may give indications of disturbances in the peripheral metabolism of catechol...
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Article
Plasma moclobemide and metabolites: lack of correlation with clinical response and biogenic amines
The concentration of the reversible monoamine oxidase type-A (MAO-A) inhibitor moclobemide (Ro 11-1163) was determined by high pressure liquid chromatography (HPLC) in the plasma of 16 depressives treated with...
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Article
Brain quinolinic acid in Alzheimer's dementia
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and c...
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Book and Conference Proceedings
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Chapter and Conference Paper
Pathobiochemistry of the extrapyramidal system: a “short note” review
Evidence is presented to show that in Parkinson’s disease (PD) there exists a topographical degeneration in the nigrostriatal dopamine system. This finding may account for response variabilities and side effec...
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Chapter and Conference Paper
The Role of Dopamine in the Control of Neurobiological Functions
It is only 30 years since dopamine (DA) was first measured in human brain tissue by Sano [98] (Fig.1). One year later Ehringer and Hornykiewicz [34] demonstrated a striatal DA deficiency in Parkinson’s disease...
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Article
Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain
Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 255% of iron...
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Article
Reduced concentrations and increased metabolism of biogenic amines in a single case of Rett-syndrome: apostmortem brain study
Preliminary data of a postmortem brain study in a single case with Rett-syndrome compared to a single control case show a severe reduction of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in most reg...
