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  1. No Access

    Article

    Reduced concentrations and increased metabolism of biogenic amines in a single case of Rett-syndrome: apostmortem brain study

    Preliminary data of a postmortem brain study in a single case with Rett-syndrome compared to a single control case show a severe reduction of dopamine (DA), noradrenaline (NA), and serotonin (5-HT) in most reg...

    Dr. T. Brücke, E. Sofic, W. Killian, A. Rett, P. Riederer in Journal of Neural Transmission (1987)

  2. No Access

    Article

    Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

    Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 255% of iron...

    E. Sofic, P. Riederer, H. Heinsen, H. Beckmann… in Journal of Neural Transmission (1988)

  3. No Access

    Book and Conference Proceedings

    The Role of Brain Dopamine

    P. Riederer, E. Sofic, C. Konradi, J. Kornhuber… in Basic and Clinical Aspects of Neuroscience (1989)

  4. No Access

    Chapter and Conference Paper

    Pathobiochemistry of the extrapyramidal system: a “short note” review

    Evidence is presented to show that in Parkinson’s disease (PD) there exists a topographical degeneration in the nigrostriatal dopamine system. This finding may account for response variabilities and side effec...

    Prof. Dr. P. Riederer, E. Sofic… in Early Diagnosis and Preventive Therapy in … (1989)

  5. No Access

    Chapter and Conference Paper

    The Role of Dopamine in the Control of Neurobiological Functions

    It is only 30 years since dopamine (DA) was first measured in human brain tissue by Sano [98] (Fig.1). One year later Ehringer and Hornykiewicz [34] demonstrated a striatal DA deficiency in Parkinson’s disease...

    P. Riederer, E. Sofic, C. Konradi, J. Kornhuber, H. Beckmann… in The Role of Brain Dopamine (1989)

  6. No Access

    Chapter

    Senile dementia of Alzheimer’s type and Parkinson’s disease: neurochemical overlaps and specific differences

    Parkinson’s disease (PD) is characterized by a clear rank order with respect to neuropathological findings. Both substantia nigra (SN) and locus coeruleus (LC) are severely damaged, whilst nucleus raphe dorsal...

    P. Riederer, E. Sofic, G. Moll… in Early Markers in Parkinson’s and Alzheimer… (1990)

  7. No Access

    Article

    Depression in Parkinson's disease: biogenic amines in CSF of “de novo” patients

    Introduction. Etiology of depression in Parkinsons disease (PD) is associated with serotonergic dysfunction. Previous studies, supporting this hypothesis, were performed on patients treated with antiparkinsonian...

    W. Kuhn, Th. Müller, M. Gerlach, E. Sofic, G. Fuchs… in Journal of Neural Transmission (1996)

  8. No Access

    Article

    Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases

    The antioxidant and pro-oxidant capacity of catecholamines (CA) and related compounds were analyzed using the oxygen radical absorbance capacity (ORAC) assay. In the assay 2,2′-azobis (2-amidino-propane) dihy...

    E. Sofic, N. Denisova, K. Youdim, V. Vatrenjak-Velagic… in Journal of Neural Transmission (2001)

  9. No Access

    Article

    Serum antioxidant capacity in neurological, psychiatric, renal diseases and cardiomyopathy

    The role of free radicals (FR) in the pathogenesis and in the progression of many diseases has been often discussed, but not widely investigated. However, the total antioxidant capacity in the serum seems to ...

    E. Sofic, A. Rustembegovic, G. Kroyer, G. Cao in Journal of Neural Transmission (2002)

  10. No Access

    Article

    Antioxidant capacity of the neurohormone melatonin

    The aim of this study was to elucidate the antioxidant behaviour of melatonin (M) and determine its activity–structure relationship. M or 5-metoxy-N acetyltriptamine is a neurohormone secreted by the pineal gl...

    E. Sofic, Z. Rimpapa, Z. Kundurovic, A. Sapcanin… in Journal of Neural Transmission (2005)

  11. No Access

    Article

    The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats

    We investigated the effects of exogenous melatonin on the thyrocytes morphology in gamma-irradiated rats under condition where the pineal gland, as a main physiological source of endogenous melatonin, was remo...

    Z. Kundurovic, E. Sofic in Journal of Neural Transmission (2006)

  12. No Access

    Article

    Antioxidant capacity in rat brain after ICV treatment with streptozotocin and alloxan — a preliminary study

    Intracerebroventricular (icv) administration of betacytotoxic drug streptozotocin (STZ) produces long-term and progressive cognitive deficits in rats, as well as deficits in cerebral glucose and energy metabol...

    A. Sapcanin, E. Sofic, I. Tahirovic, M. Salkovic-Petrisic… in Neurotoxicity Research (2008)

  13. No Access

    Article

    Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30

    Low intracerebroventricular (icv) doses of streptozotocin (STZ) produce regionally specific brain neurochemical changes in rats that are similar to those found in the brain of patients with sporadic Alzheimer’...

    E. Sofic, M. Salkovic-Petrisic, I. Tahirovic, A. Sapcanin… in Journal of Neural Transmission (2015)