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Article
Effect of Xe/O2 Inhalation on Hemostasis in Experimental Thromboplastin Pneumonitis
We studied the effectiveness of Xe/O2 mixture inhalation (30% Xe and 70% O2, 20 min for 5 days) in a model of experimental thromboplastin pneumonitis. Inhalation of the studied mixture decreased the intensity of ...
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Article
Effect of Paclitaxel on the Hemostatic Potential of the Blood in the Experiment
The duration and severity of prothrombotic effects of the maximum tolerated dose of paclitaxel (40 mg/kg) were evaluated in intact outbred mice. Hemostasis was assessed before and on days 1, 2, 5, 7, 10, 15, 2...
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Article
Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsi...
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Article
Erythropoiesis-Stimulating Properties of Anthocyanin-Containing Complex from Sorbus aucuparia L. in Cytostatic Anemic Syndrome in Mice with Lewis Lung Carcinoma
The results of studying the effect of the anthocyanin-containing complex from Sorbus aucuparia L. on the main indicators of erythropoiesis in the blood and bone marrow of mice with Lewis lung carcinoma against th...
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Article
Erythropoesis-Stimulating Properties of Anthocyanin-Containing Complexes in Cytostatic Anemic Syndrome
We studied the effect of an anthocyanin-containing complex from Sorbus aucuparia L. on the main indicators of erythropoiesis in the blood and bone marrow of mice against the background of doxorubicin treatment. I...
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Article
Pharmacological Correction of Cisplatin-Induced Hemostatic Disorders
A single intraperitoneal administration of cisplatin in the MTD to outbred female mice disturbed hemostasis and formed the procoagulant phenotype of hemostatic potential on days 7-10 culminating in a pronounce...
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Article
Changes in Hemostasis System in Outbred Female Mice with Cisplatin-Induced Procoagulant Status
Procoagulant status was modeled in outbred female mice by single injection of cisplatin in a maximum tolerated dose and hemostasis parameters monitored over 30 days by methods of coagulogram and low-frequency ...
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Article
Dalayed Effects of Antitumor Drug Paclitaxel on the Hereditary Material and Hemopoietic System of CBA Mice
Paclitaxel in a single MTD of 40 mg/kg caused chromosome aberrations and genome changes (polyploidy) in the bone marrow cells of mice early and 3 months after the injection. The quantity of early precursors of...
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Article
Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing the Efficiency of Tumor Chemotherapy
The composition of phenolic compounds of rowanberry (Sorbus aucuparia L.) fruit extracts prepared with 40% ethanol and 95% acidified ethanol was studied. The differences in the content of flavonoids, including...
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Article
Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.
The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitum...
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Article
Age features peripheral erythron rats and its status with experimental cardiosclerosis
The features of the peripheral erythron in rats 4, 12, and 24 months old were studied. Each age group (n = 20) consisted of 10 intact animals and 10 animals with postinfarction cardiosclerosis (PICS). In the grou...
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Article
Pharmacologic correction of paclitaxel induced gene- and myelotoxicity with an extract of the hairy root culture from Scutellaria baicalensis
The gene protection effects of the hairy transgenic root extract, obtained as a result of the transformation of Scutellaria baicalensis into Agrobacterium rhizogenes, were revealed on a model of paclitaxel induce...
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Article
Hemo-rheological status of young Wistar–Kyoto rats
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Article
Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, 99mTc-Al2O3
We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, 99mTc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative p...
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Article
Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period
We studied the dynamics of erythropoiesis in CBA mice during gestation against the background of treatment with iron-binding drug. The mechanisms of suppression of the bone marrow erythroid stem were evaluated...
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Article
Study of Subchronic Toxicity of Relatox on Sexually Immature Animals
Intramuscular injections of Relatox in therapeutic and toxic doses to young outbred laboratory rats for 14 days caused no changes in the peripheral blood and bone marrow parameters, serum biochemical parameter...
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Article
Quantitative Indexes of Leukocytes in Spontaneously Hypertensive Rats During Various Periods of Arterial Hypertension Development
SHR rats were examined in the period before arterial hypertension development (5th week), during the increase in BP (6th-10th weeks), and under conditions of constantly elevated BP (11th-12th weeks). The total...
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Article
Stoichiometry and do** effects on cation ordering in LiNbO3 crystals
The cation disorder in stoichiometric and congruent lithium niobate crystals and also in congruent crystals doped with Y3+ or Gd3+ has been studied by X-ray diffraction and Raman scattering spectroscopy using vac...
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Article
Steel-casting nozzles made of fused quartz by vibration casting
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Article
Refractory backings for single-sided welding of steel structures
