-
Article
Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study
Zinc (Zn) plays an essential role in many biological processes including immune response. Impaired Zn status promotes immune dysfunction, and it has been associated with enhanced chronic inflammation during ag...
-
Article
Open AccessMy Mind Project: the effects of cognitive training for elderly—the study protocol of a prospective randomized intervention study
Cognitive decline and dementia represent a key problem for public health as they heavily impair social functioning and independent living. The development of new strategies to support recommendations for patie...
-
Article
Association among 1267 A/G HSP70-2, −308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population
Proinflammatory cytokines and heat shock proteins play relevant roles in the pathogenesis of inflammatory diseases. We investigated whether Hsp70 1267 A/G and TNF-α −308 G/A polymorphisms are associated with p...
-
Article
Dietary habits and ageing in a sample of Italian older people
To analyse dietary habits and explore the role of socioeconomic status in a sample of elderly Italians.
-
Article
BMI, life-style and psychological conditions in a sample of elderly italian men and women
To identify the relationship among cognitive status, psychological conditions, anthropometric measurements and life-style in a sample of elderly Italian men and women.
-
Article
Chronobiology and Effects of the Age on the Immune Function: Nutritional and Genetic Background
Mocchegiani, E., Giacconi, R., Cipriano, C. and Malavolta, M., 2007. Chronobiology and effects of the age on the immune function: Nutritional and genetic background. Veterinary Research Communications, 31(Suppl. ...
-
Article
Antioxidant enzyme activities in healthy old subjects: influence of age, gender and zinc status
Enzymatic activities of plasma superoxide dismutase (pSOD), catalase (CAT) and glutathione peroxidase (GPx) and erythrocyte superoxide dismutase (eSOD) were assayed in 981 healthy community dwelling old subjec...
-
Article
Oxidative stress and brain aging: is zinc the link?
Zn2+ dyshomeostasis has been strongly linked to neuronal injury in many neurological conditions. Toxic accumulation of intracellular free Zn2+ ([Zn2+]i) may result from either flux of the cation through glutamate...
-
Article
Open AccessRole of zinc and α2macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma
Decreased natural killer (NK) activity as well as interleukin 2 (IL-2) are risk factors for the progression of cervical carcinoma. NK activity and IL-2 may be thymus controlled. Plasma levels of active thymuli...
-
Article
Thyroid and thymic endocrine function and survival in severely traumatized patients with or without head injury
Functional links among the brain, endocrine and immune system have been described previously. An impairment of both immunological defence mechanisms and thyroid hormone turnover was present in trauma condition...
-
Chapter
Plasticity of Neuroendocrine-Immune Interactions During Aging
A good body of experimental evidences now supports the existence of numerous interactions among the nervous, endocrine and immune systems. Communication between these networks is mediated by humoral mediators,...
-
Article
Prolactin, thymulin and zinc in chronic hemodialysis: effect of renal transplant
The interrelationships between PRL, thymulin and Zn, were studied in 25 patients with chronic renal failure (CRF) undergoing kidney transplantation and immunosuppressed with cyclosporine A (CsA). The possible ...
-
Chapter
Thymulin Deficiency and Low T3 Syndrome in Infants With Low-Birth-Weight Syndromes
Several immunological abnormalities have been reported during the first week of life in premature and/or low-weight newborns. Impaired thymic function and particularly reduced capacity of the thymus to produce...
-
Chapter
Thymus-Neuroendocrine Network
The idea that the thymus might be considered as an endocrine gland integrated in the complex hormonal network regulating the growth and the internal homeostasis of high organisms was first suggested by the obs...
-
Article
Increased immunological efficiency in young mice by short-term treatment with L-thyroxine
Treatment of young mice with L-thyroxine increases theircapacity to form hemolytic plaques after sheep erythrocyte immunization. Such an increment is indepedent from the quantity of antigenic challenge, from s...
