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Article
What does general paediatric surgery involve? An audit of paediatric cases in 1 year
As all tertiary paediatric hospitals are based in the capital of Dublin, it is therefore necessary for general surgeons in centres outside of Dublin to undertake routine elective and emergency paediatric surge...
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Article
“Is General Surgery Still Relevant to the Subspecialised Trainee?” A 10 Year Comparison of General Versus Specialty Surgical Practice
The splintering of general surgery into subspecialties in the past decade has brought into question the relevance of a continued emphasis on traditional general surgical training. With the majority of trainees...
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Article
Multivariate analysis of MLH1 c.1664T>C (p.Leu555Pro) mismatch repair gene variant demonstrates its pathogenicity
Genetic testing of an Irish kindred identified an exonic nucleotide substitution c.1664T>C (p.Leu555Pro) in the MLH1 mismatch repair (MMR) gene. This previously unreported variant is classified as a “variant of u...
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Article
Enhanced recovery after elective colorectal surgery: now the standard of care
Enhanced recovery programmes have been studied in randomised trials with evidence of quicker recovery of gut function, reduced morbidity, mortality and hospital stay and improved physiological and nutritional ...
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Article
Open AccessBacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-κB-dependent activation of the urokinase plasminogen activator system
Perioperative exposure to lipopolysaccharide (LPS) is associated with accelerated metastatic colorectal tumour growth. LPS directly affects cells through Toll-like receptor 4 (TLR-4) and the transcription fact...
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Article
Sestamibi scan-directed, minimally invasive video-assisted parathyroidectomy: an effective treatment for solitary parathyroid adenoma
Solitary adenomas have been shown to be responsible for almost 90% of cases of primary hyperparathyroidism.
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Article
Open AccessInhibition of urokinase plasminogen activator with a novel enzyme inhibitor, wxc-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases
The urokinase plasminogen activator (u-PA) is intimately associated with tumour invasion and metastases. Surgery facilitates accelerated metastatic tumour growth in murine models, a phenomenon related to eleva...
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Article
Open AccessExploitation of the Toll-like receptor system in cancer: a doubled-edged sword?
The toll-like receptor (TLR) system constitutes a pylogenetically ancient, evolutionary conserved, archetypal pattern recognition system, which underpins pathogen recognition by and activation of the immune sy...
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Article
The effect of sex hormones on the juxtaglomerular index of female mice
La testostérone, administrée de faćcon chronique à des souris femelles provoque und diminution statistiquement significative de l'index juxtaglomérulaire. Les femelles traitées par la progestérone ou les souri...
