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  1. No Access

    Article

    Influence of rat strain on P-glycoprotein expression in cultured hepatocytes

    The amount and activity of the multi-drug transport P-glycoprotein (Pgp) have been measured in cultured hepatocytes derived from different rat strains. A marked increase in Pgp, as revealed by Western blotting...

    E. Chieli, N. Romiti, F. Cervelli, A. Paolicchi, R. Tongiani in Cell Biology and Toxicology (1994)

  2. No Access

    Article

    Assessment of P-glycoprotein-dependent drug transport in isolated rat hepatocytes using rhodamine 123

    To test the activity of P-170 glycoprotein in isolated hepatocytes, a method has been developed employing the fluorescent dye rhodamine 123 (R-123). The uptake of R-123 by both freshly isolated and 4-hr-plated...

    E. Chieli, E. Santoni Rugiu, F. Cervelli, A. Paolicchi… in Cell Biology and Toxicology (1993)

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    Article

    Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide

    The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated. Hepatic microsomes from acetone-pretreated rats showed a signif...

    E. Chieli, M. Saviozzi, P. Puccini, V. Longo, P. G. Gervasi in Archives of Toxicology (1990)

  4. No Access

    Article

    Studies on in vitro peroxidation of liver lipids in ethanol-treated rats

    It has been confirmed that lipid peroxidation of liver homogenates is increased following acute ethanol intoxication. Studies with recombined fractions of the liver suggest that the cause for the ethanol-induc...

    M. Comporti, A. Benedetti, E. Chieli in Lipids (1973)