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Article
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity
E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally ...
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Article
Open Access3' tag digital gene expression profiling of human brain and universal reference RNA using Illumina Genome Analyzer
Massive parallel sequencing has the potential to replace microarrays as the method for transcriptome profiling. Currently there are two protocols: full-length RNA sequencing (RNA-SEQ) and 3'-tag digital gene e...
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Article
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Transforming growth factor β (TGF-β) induces both apoptosis and cell-cycle arrest in some cell lines, but only growth arrest in others1. It is not clear how this differential response to TGF-β is specified. Smad ...
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Chapter
Glucocorticoid Regulation of Cell Proliferation
Initiation of DNA replication in non-embryonic cells requires passage through an irreversible step in late Gl that has come to be called the restriction point. The restriction point was originally defined as t...
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Chapter
TGF-β Inhibition of Intestinal Epithelial Cell Proliferation: G1 Cyclins, Cyclin-Dependent Kinases, and Cyclin Kinase Inhibitors
Colon carcinogenesis is a multistep process involving alterations in the normal replication of intestinal epithelial cells Vogelstein et al., 1988; Cameron et al., 1990; Vogelstein, 1990. In recent years, ther...