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  1. Article

    Open Access

    Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

    T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nuc...

    A. Schrader, G. Crispatzu, S. Oberbeck, P. Mayer, S. Pützer… in Nature Communications (2018)

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  2. No Access

    Article

    Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

    Treatment resistance becomes a challenge at some point in the course of most patients with chronic lymphocytic leukemia (CLL). This applies to fludarabine-based regimens, and is also an increasing concern in t...

    G Lohmann, E Vasyutina, J Bloehdorn, N Reinart, J I Schneider, V Babu… in Leukemia (2017)

  3. No Access

    Article

    The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL

    Dysregulated T-cell leukemia/lymphoma-1A (TCL1A), a modulator in B-cell receptor (BCR) signaling, is causally implicated in chronic lymphocytic leukemia (CLL). However, the mechanisms of the perturbed TCL1A re...

    E Vasyutina, J M Boucas, J Bloehdorn, C Aszyk, G Crispatzu, M Stiefelhagen… in Leukemia (2015)

  4. No Access

    Article

    Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia

    The tissue microenvironment in chronic lymphocytic leukemia (CLL) has an increasingly recognized role in disease progression, but the molecular mechanisms of cross talk between CLL cells and their microenviron...

    M Sivina, E Hartmann, E Vasyutina, J M Boucas, A Breuer, M J Keating… in Leukemia (2012)