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Article
Presence of t(14;18) positive cells in blood and bone marrow does not predict outcome in follicular lymphoma
Follicular Lymphoma International Prognostic Index—FLIPI is an established clinical predictor for outcome in follicular lymphoma. The role of molecular abnormalities in blood and bone marrow of follicular lymp...
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Article
Open AccessTP53 status determines clinical significance of ERBB2 expression in ovarian cancer
ERBB2 expression has been found in 19 to 44% of ovarian carcinomas; however, its predictive value has not been demonstrated, and trastuzumab has not found clinical application in ovarian cancer patients. We ev...
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Article
Open AccessEvaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen
In cell line studies, BCL-2, BAX, as well as novel MEK1 protein levels have strong influence on ovarian cancer response to cisplatin-based chemotherapy. However, such associations have not been demonstrated cl...
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Article
Rituximab (Mabthera™, rituxan™) in patients with recurrent indolent lymphoma
The objective of this multiinstitutional study was to evaluate the safety and efficacy of rituximab at standard four weekly doses in patients with recurrent indolent lymphoma. Thirty-eight patients entered int...
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Article
CN3OP: an active regimen in patients with relapsed/refractory Hodgkin's lymphoma
Patients with recurrent or refractory Hodgkin's and non-Hodgkin's lymphoma are increasingly being treated with high-dose therapy and hematopoietic cell transplantation. As minimal disease status at the time of...
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Article
Open AccessSpontaneous apoptosis in ovarian carcinomas: a positive association with p53 gene mutation is dependent on growth fraction
Changes in cell survival contribute to tumour development, influence tumour biology and its response to chemotherapy. p53 gene alterations should negatively affect apoptosis by impaired p53-dependent apoptotic re...
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Article
Uptake and binding of cytoplasmic DNA by wheat embryo cell nuclei
Cytoplasmic non-mitochondrial DNA was selectively labelled and isolated in a linear single-stranded form from early wheat embryos. The isolated preparation was readily taken up by wheat embryo cell nuclei and ...
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Article
Isolation of a single-stranded extrachromosomal DNA from germinating wheat embryos
Newly-synthesized cytoplasmic non-mitochondrial DNA was isolated from wheat embryos which had been germinated in the presence of [14C]-thymidine for a time period not long enough to trigger the first post-dormant...