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Article
Open AccessThe validation study on a three-dimensional burn estimation smart-phone application: accurate, free and fast?
Accurate total body surface area burned (TBSAB) estimation is a crucial aspect of early burn management. It helps guide resuscitation and is essential in the calculation of fluid requirements. Conventional met...
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Article
Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079)
Background This study investigated the activity of MK-2206, an AKT inhibitor, in metastatic or recurrent nasopharyngeal carcinoma (NPC). Method Oral MK-2206 at a dose of 200 mg was admini...
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Article
Functions of TAp63 and p53 in restraining the development of metastatic cancer
Many tumours harbour mutations in the p53 tumour-suppressor gene that result in the expression of a mutant p53 protein. This mutant p53 protein has, in most cases, lost wild-type transcriptional activity and c...
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Article
Open AccessGraft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation
While nonmyeloablative peripheral blood stem cell transplantation (NST) has shown efficacy against several solid tumors, it is untested in nasopharyngeal cancer (NPC). In a phase II clinical trial, 21 patients...
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Open AccessReply: Surgery vs chemoRT for locally advanced operable head and neck cancers
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Article
A New Dislocation-Dynamics Model and Its Application in Thin Film-Substrate Systems
Based on the physical background, a new dislocation dynamics model fully incorporating the interaction among differential dislocation segments is developed to simulate 3D dislocation motion in crystals. As the...
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Article
Open AccessSurgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison
We compared concurrent combination chemotherapy and radiotherapy with surgery and adjuvant radiotherapy in patients with stage III/IV nonmetastatic squamous cell head and neck cancer. Patients with non-nasopha...
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Article
Open AccessGefitinib is more effective in never-smokers with non-small-cell lung cancer: experience among Asian patients
We retrospectively analysed the results of patients with advanced non-small-cell lung cancer treated with gefitinib to derive clinical factors predictive of response and a favourable survival outcome. Patients...
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Open AccessValidation of a new prognostic index score for disseminated nasopharyngeal carcinoma
Patients with metastatic nasopharyngeal carcinoma have variable survival outcomes. We previously designed a scoring system to better prognosticate these patients. Here, we report results on validation of this ...
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Article
Open AccessQuick-FLIC: validation of a short questionnaire for assessing quality of life of cancer patients
A practically useful measure of quality of life should be simple and quick to complete. A shortened Chinese version of the Functional Living Index – Cancer (FLIC) was recently proposed and was called Quick-FLI...
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Article
Dislocation Dynamics in Semiconductor Thin Film-Substrate Systems
A discrete dislocation dynamics model is developed to establish the equations of motion for three-dimensional interacting dislocation loops in the semiconductor thin film–substrate system. The film is assumed ...
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Open AccessA Bayesian re-assessment of two Phase II trials of gemcitabine in metastatic nasopharyngeal cancer
The Simon two-stage minimax design is a popular statistical design used in Phase II clinical trials. The analysis of the data arising from the design typically involves the use of frequentist statistics. This ...
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Article
Control of emsis by intravenous granisetron in breast cancer patients treated with 5-FU, epirubicin and cyclophosphamide
Granisetron, a potent and selective 5-hydroxytryptamine receptor (5-HT3) antagonist was reported to be an effective antiemetic agent both in animal studies and in patients given highly emetogenic chemotherapy. A ...
