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Article
Open AccessShort-term changes observed in multiparametric liver MRI following therapy with direct-acting antivirals in chronic hepatitis C virus patients
We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before direct-acting antiviral (DAA) therapy and after treatment completion (within 12 weeks of la...
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Article
Open AccessFood-specific sublingual immunotherapy is well tolerated and safe in healthy dogs: a blind, randomized, placebo-controlled study
Food allergies are increasing in prevalence but no treatment strategies are currently available to cure dogs with food allergy. Over the past decade, experimental food allergen-specific sublingual immunotherap...
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Article
Open AccessPotential immunosuppressive effects of Escherichia coli O157:H7 experimental infection on the bovine host
Enterohaemorrhagic Escherichia coli (EHEC), like E. coli O157:H7 are frequently detected in bovine faecal samples at slaughter. Cattle do not show clinical symptoms upon infection, but for humans the consequences...
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Article
Phase I trial and pharmacokinetic study of high-dose clofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia
We conducted a phase I trial to determine the maximum tolerated dose (MTD) of clofarabine with high-dose busulfan followed by allogeneic stem cell transplantation (SCT) in patients with high-risk and refractor...
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Article
Non-invasive testing
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Article
Influence of preapheresis clinical factors on the efficiency of CD34+ cell collection by large-volume apheresis
We evaluated 120 leukapheresis procedures (93 patients), in order to detect clinical factors that influence the efficiency of CD34+ collection using Cobe Spectra™ cell separators. Hematocrit was >27% and plate...
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Chapter and Conference Paper
Induction of Milk IgA Antibodies by Porcine Respiratory Coronavirus Infection
An ELISA was developed to examine the prevalence of TGEV-specific immunoglobulin (Ig)A in the milk of sows, infected in the field with PRCV or with TGEV. It was shown that previous PRCV-infections can induce t...
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Chapter and Conference Paper
The HISS Project — A Pilot Site’s View
The NHS Review published in 1989 and the commitment to Resource Management has emphasised the need for a comprehensive and robust information system to enable hospitals to operate effectively in the new enviro...
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Chapter and Conference Paper
Sites of Replication of a Porcine Respiratory Coronavirus in 5-Week-Old Pigs with or without Maternal Antibodies
On farms, where the porcine respiratory Coronavirus (PRCV) is enzootic, pigs usually become infected between 5 and 10 weeks of age while losing their maternal antibodies. It was examined whether PRCV replicate...
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Article
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets
In 45 newly-weaned 3 to 4-week-old piglets, diarrhoea was induced by a combined infection with transmissible gastroenteritis (TGE) virus and enterotoxigenic E. coli (ETEC) strains. In untreated control animals th...
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Article
Escherichia coli sepsis and endotoxemia in conscious young pigs
In conscious pigs the influence of intravenous infusion of live E. coli (7×108/kg), of the equivalent amount of endotoxin (20 μg/kg) or of a high dose of endotoxin (2.5 mg/kg) on the hemodynamic, clinical and pat...
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Article
Pathophysiology of diarrhoea induced by a combined infection with transmissible gastroenteritis virus and enterotoxigenic Escherichia coli in newly-weaned piglets and the effect of flurbiprofen treatment
In newly-weaned 3–4 week old piglets (n=29) diarrhoea (100%) and vomiting (65%) were induced by inoculation with transmissible gastroenteritis virus and enterotoxigenic E. coli strains (0149:K91:K88ac; LT, STa an...
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Chapter
In Vitro Adhesion of K88 Positive E. Coli to Intestinal Villi of Just-weaned Piglets
Enterotoxigenic E. coli (ETEC) strains are an important cause of diarrhoea in young animals and children. These strains produce enterotoxins which stimulate small intestinal electrolyte and fluid secretion. Mo...
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Chapter
Monoclonal Antibodies Against Estrogen Receptor: Specificity, Sensitivity and Potential Applications
A study of immunohistochemical localization of estrogen receptor in one hundred and thirty-four human breast cancers and twenty-three metastatic lesions shows sensitivities and specificities of 91% as compared...
