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  1. Article

    Open Access

    Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation

    Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role of the mitochondrial NAD+-dependent deacetylase, Sirtuin-3 (SI...

    Andrew R. Hall, Qutuba G. Karwi, Sanjeev Kumar, Rachel Dongworth… in Scientific Reports (2022)

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  2. Article

    Open Access

    Structural basis for a complex I mutation that blocks pathological ROS production

    Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia–reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDN...

    Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević… in Nature Communications (2021)

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  3. Article

    Open Access

    Intracellular sodium elevation reprograms cardiac metabolism

    Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myoc...

    Dunja Aksentijević, Anja Karlstaedt, Marina V. Basalay… in Nature Communications (2020)

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  4. No Access

    Article

    Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

    A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to ischaemia-reperfusion injury; pharmacological inhibitio...

    Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević… in Nature (2014)