25 Result(s)
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Biomedicine
Nanotechnology
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Article
Stable inhibition of choroidal neovascularization by adeno-associated virus 2/8-vectored bispecific molecules
Neovascular age-related macular degeneration (nAMD) causes severe visual impairment. Pigment epithelium-derived factor (PEDF), soluble CD59 (sCD59), and soluble fms-like tyrosine kinase-1 (sFLT-1) are potentia...
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Open AccessPolystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes
Increasing attention is being paid to the environmental and health impacts of nanoplastics (NPs) pollution. Exposure to nanoplastics (NPs) with different charges and functional groups may have different advers...
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Open AccessPolystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo
Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, and have raised concerns regarding their potential risks to human health, particularly neurotoxicity. Th...
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Overexpressed ski efficiently promotes neurorestoration, increases neuronal regeneration, and reduces astrogliosis after traumatic brain injury
Traumatic brain injury (TBI) survivors suffer from long-term disability and neuropsychiatric sequelae due to irreparable brain tissue destruction. However, there are still few efficient therapies to promote ne...
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Open AccessRETRACTED ARTICLE: Inhibition of miR-296-5p protects the heart from cardiac hypertrophy by targeting CACNG6
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Open AccessThe critical role of endothelial function in fine particulate matter-induced atherosclerosis
Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate m...
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Retraction Note: Inhibition of miR-296-5p protects the heart from cardiac hypertrophy by targeting CACNG6
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessSilica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction
Wide applications of nanoparticles (NPs) have raised increasing concerns about safety to humans. Oxidative stress and inflammation are extensively investigated as mechanisms for NPs-induced toxicity. Autophagy...
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Estrogen administration reduces the risk of pulmonary arterial hypertension by modulating the miR-133a signaling pathways in rats
We aimed to investigate how estrogen (ES) is implicated in the pathogenesis of pulmonary arterial hypertension (PAH) potentially by reducing the extent of vascular remodeling in females. HE assay, Western Blot...
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Chapter
Dendrimer-Based Tumor-targeted Systems
Dendrimers have a unique three-dimensional structure, highly branched macromolecular features, and abundant terminal functional groups. These features of dendrimers support their uses as universal nanoplatform...
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Chapter
Barriers for Tumor Drug Delivery
The ultimate goal of cancer nanomedicine is to specifically increase the drug accumulation in tumor and reduce side effects. Although nanomedicine has made great progress in recent decades, its delivery effica...
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Open AccessIron oxide nanoparticles induce reversible endothelial-to-mesenchymal transition in vascular endothelial cells at acutely non-cytotoxic concentrations
Iron oxide nanoparticles (IONPs) have been extensively studied in different biomedical fields. Recently, the non-cytotoxic concentration of IONPs induced cell-specific response raised concern of their safety. ...
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The Strategies of Nanomaterials for Therapy
Brain diseases, including brain tumor, Alzheimer’s and Parkinson’s diseases, and stroke, are becoming increasingly widespread in the aging population. However, due to our limited knowledge of the pathogenesis ...
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Open AccessOptimization of viral protein ratios for production of rAAV serotype 5 in the baculovirus system
Recombinant adeno-associated virus (rAAV) has become the vector of choice for the development of novel human gene therapies. High-yield manufacturing of high-quality vectors can be achieved using the baculovir...
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Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models
Cancer stem cells (CSCs), which are a rare population in any type of cancer, including colon cancer, are tumorigenic and responsible for cancer recurrence and metastasis. CSCs have been isolated from a number ...
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Article
Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice
Impaired burn wound healing in the elderly represents a major clinical problem. Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that orchestrates the cellular response to hypoxia. Its actions...
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Effective antitumor gene therapy delivered by polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide micelles
Non-viral vesicle composing of low-molecular weight polyethylenimine-conjugated stearic acid-g-chitosan oligosaccharide (CSOSA-g-PEI) was synthesized for gene delivery and therapy. The synthesized CSOSA-g-PEI ...
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Article
Combination gene therapy targeting on interleukin-1β and RANKL for wear debris-induced aseptic loosening
This study investigated the efficacy of a combination gene therapy to repress interleukin-1 (IL-1) and receptor activator of nuclear factor NF-kappa B ligand (RANKL) for the treatment of particulate debris-ind...
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Construction of a novel expression cassette for increasing transgene expression in vivo in endothelial cells of large blood vessels
The success of gene therapy hinges on achievement of adequate transgene expression. To ensure high transgene expression, many gene-therapy vectors include highly active virus-derived transcriptional elements. ...
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Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers
Methods to improve plasmid-mediated transgene expression are needed for gene medicine and gene vaccination applications. To maintain a low risk of insertional mutagenesis-mediated gene activation, expression-a...
