3 Result(s)
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Chapter and Conference Paper
Pharmacokinetic studies of (—)-deprenyl and some of its metabolites in mouse
(—)-Deprenyl is a selective irreversible inhibitor of MAO-B. The parent compound is responsible for the enzyme inhibitory effect, but its metabolites are also playing a role in the complex pharmacological acti...
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Chapter and Conference Paper
The pharmacology of B-type selective monoamine oxidase inhibitors; milestones in (−)-deprenyl research
(−)-deprenyl cannot be considered as a simple, selective inhibitor of MAO-B. It increases the dopaminergic tone in the central nervous system by a complex mechanism. The MAO-B inhibition could result in a pote...
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Chapter and Conference Paper
Behaviour of (-)-deprenyl and its analogues
A number of new deprenyl analogues were synthesized during the last decades and structure-activity relationship studies were carried out with the compounds. Among these derivatives U-1424 [N-methyl-N-pro-pargy...
