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  1. Article

    Open Access

    Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

    Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms. Here, we demonst...

    Jianxing Yin, **efeng Wang, **n Ge, Fangshu Ding, Zhumei Shi… in Nature Communications (2023)

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  2. Article

    Open Access

    JAC1 targets YY1 mediated JWA/p38 MAPK signaling to inhibit proliferation and induce apoptosis in TNBC

    Triple negative breast cancer (TNBC) is a type of breast cancer with poor prognosis, and has no ideal therapeutic target and ideal medicine. Downregulation of JWA is closely related to the poor overall surviva...

    Zurong Zhai, Yanlin Ren, Chuanjun Shu, Dongyin Chen, … in Cell Death Discovery (2022)

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  3. Article

    Open Access

    JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling

    The overexpression of HER2 is associated with a malignant proliferation of breast cancer. In this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the proliferation of HER2-pos...

    Yanlin Ren, Dongyin Chen, Zurong Zhai, Junjie Chen, Ai** Li… in Cell Death Discovery (2021)

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