23 Result(s)
within
DongDong Wang
Life Sciences
-
Article
An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α
Peroxisome proliferator-activated receptor-α (PPAR-α) belonging to the nuclear hormone receptor superfamily is a promising target for CVDs which mechanistically improves the production of high-density lipid as...
-
Article
Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6-Mediated NF-κB and MAPKs Signaling Pathways
As a probiotic, Weizmannia coagulans (W. coagulans) is often used in food and medicine to regulate intestinal flora and exert anti-inflammatory effects. In this study, the anti-acne efficacy and mechanism of extr...
-
Article
Open AccessUSP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation
Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promo...
-
Article
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits
Growing evidence demonstrates the metabolic benefits of repeated cold exposure in humans. Here, we argue that skeletal muscle thermogenesis, rather than the stimulation of thermogenic adipose tissue, is requir...
-
Article
Transcriptome Profile in a Susceptible Pear ‘Zaosu’ (Pyrus bretschneideri Rehd.)–Valsa pyri Interaction
Pear production was seriously threatened by Valsa canker, a notorious disease caused by the necrotrophic fungus Valsa pyri (Vp), but the molecular mechanism is elusive. Currently, the dynamic gene expression prof...
-
Article
Open AccessAnthocyanin regulatory networks in Solanum tuberosum L. leaves elucidated via integrated metabolomics, transcriptomics, and StAN1 overexpression
Anthocyanins, which account for color variation and remove reactive oxygen species, are widely synthesized in plant tissues and organs. Using targeted metabolomics and nanopore full-length transcriptomics, inc...
-
Article
Open AccessPINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-ind...
-
Article
Cyclic nucleotide gated channel genes (CNGCs) in Rosaceae: genome-wide annotation, evolution and the roles on Valsa canker resistance
In Rosaceae , tandem duplication caused the drastic expansion of CNGC gene family Group I. The members MdCN11 and ...
-
Article
Can only one physiological trait determinate the adverse effect of green fluorescent protein (GFP) incorporation on Vibrio virulence?
Green fluorescent protein (GFP) has been used extensively for in situ animal studies that follow up bacterial infection under epifluorescence microscopy. It is assumed that GFP is acting as a “neutral” protein...
-
Article
Open AccessEvolutionary history of the C-repeat binding factor/dehydration-responsive element-binding 1 (CBF/DREB1) protein family in 43 plant species and characterization of CBF/DREB1 proteins in Solanum tuberosum
Plants are easily affected by temperature variations, and high temperature (heat stress) and low temperature (cold stress) will lead to poor plant development and reduce crop yields. Therefore, it is very impo...
-
Article
Evolutionary history of the heat shock protein 90 (Hsp90) family of 43 plants and characterization of Hsp90s in Solanum tuberosum
Heat shock protein 90 genes/proteins (Hsp90s) are related to the stress resistance found in various plant species. These proteins affect the growth and development of plants and have important effects on the p...
-
Article
Open AccessEvolutionary significance of amino acid permease transporters in 17 plants from Chlorophyta to Angiospermae
Nitrogen is an indispensable nutrient for plant growth. It is used and transported in the form of amino acids in living organisms. Transporting amino acids to various parts of plants requires relevant transpor...
-
Article
Open AccessA quick and efficient hydroponic potato infection method for evaluating potato resistance and Ralstonia solanacearum virulence
Potato, the third most important crop worldwide, plays a critical role in human food security. Brown rot, one of the most destructive potato diseases caused by Ralstonia solanacearum, results in huge economic los...
-
Article
Correction to: Split N and P addition decreases straw mineralization and the priming effect of a paddy soil: a 100-day incubation experiment
The author regret that the above article originally published with an error in the equation under “Calculation of GHG emission, PE, C-mineralization, microbial C use efficiency, and enzyme activity” section. T...
-
Article
Split N and P addition decreases straw mineralization and the priming effect of a paddy soil: a 100-day incubation experiment
The effect of mineral fertilization and its application pattern on microbial activity and the subsequent CO2 and CH4 emissions arising from soil organic matter (SOM) or added substrate remains unclear. We quantif...
-
Article
Open AccessThe formation and accumulation of protein-networks by physical interactions in the rapid occlusion of laticifer cells in rubber tree undergoing successive mechanical wounding
Although the wound response of plants has been extensively studied, little is known of the rapid occlusion of wounded cell itself. The laticifer in rubber tree is a specific type of tissue for natural rubber b...
-
Article
Open AccessComparative transcriptome analysis reveals the regulatory networks of cytokinin in promoting the floral feminization in the oil plant Sapium sebiferum
Sapium sebiferum, whose seeds contain high level of fatty acids, has been considered as one of the most important oil plants. However, the high male to female flower ratio limited the seed yield improvement and i...
-
Article
Open AccessGenome-wide analysis of the potato Hsp20 gene family: identification, genomic organization and expression profiles in response to heat stress
Heat shock proteins (Hsps) are essential components in plant tolerance mechanism under various abiotic stresses. Hsp20 is the major family of heat shock proteins, but little of Hsp20 family is known in potato (So...
-
Article
Open AccessPre-synaptic TrkB in basolateral amygdala neurons mediates BDNF signaling transmission in memory extinction
Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, TrkB, play an essential role in memory extinction. Our previous work has shown that JIP3 (JNK interacted protein 3) mediates anterograde...
-
Article
Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan
In this study, we synthesized a novel water-soluble low molecular chitosan (LMC) derivative through Vilsmeier reaction and reductive amination reaction. The derivative was characterized by UV-visible spectrosc...
