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Article
Seismic performance of a new type of prefabricated bridge pier with cast-in-place UHPC jacketing
Accelerated bridge construction (ABC) is prevalent all over the world attributable to its technical advantages including the higher construction efficiency, less traffic disruption, and higher construction qua...
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Article
Open AccessInhibition of EZH2 alleviates SAHA-induced senescence-associated secretion phenotype in small cell lung cancer cells
Chemotherapy has been widely used in small cell lung cancer (SCLC) treatment in the past decades. However, SCLC is easy to recur after chemotherapy. The senescence of cancer cells during chemotherapy is one of...
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Article
Open AccessINSurVeyor: improving insertion calling from short read sequencing data
Insertions are one of the major types of structural variations and are defined as the addition of 50 nucleotides or more into a DNA sequence. Several methods exist to detect insertions from next-generation seq...
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Article
Open AccessA novel maxillary transverse deficiency diagnostic method based on ideal teeth position
This study proposed a novel maxillary transverse deficiency diagnostic method and evaluated the skeletal Class I and the mild skeletal Class III groups.
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Article
Combined analysis of receptor expression reflects inter-and intra-tumor heterogeneity in HR+/HER2+ breast cancer
Hormone receptor-positive and human epidermal growth factor receptor 2-positive (HR+/HER2+ breast cancer comprise approximately 5–10% of all invasive breast cancers. However, the lack of knowledge regarding th...
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Article
Open AccessSHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment
SHON nuclear expression (SHON-Nuc+) was previously reported to predict clinical outcomes to tamoxifen therapy in ERα+ breast cancer (BC). Herein we determined if SHON expression detected by specific monoclonal an...
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Article
Design of iron-ion-doped pomelo peel biochar composites towards removal of organic pollutants
After treated with saturated iron(II) chloride water solution at pH ~ 2, pomelo peel was used as precursor for preparation of 3 biochar composites (named CFe1, CFe2 and CFe3, accordingly) via hydrothermal trea...
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Article
Open AccessNetrin-1 promotes glioma growth by activating NF-κB via UNC5A
Gliomas, a common type of brain tumor, are characterized by aggressive infiltration, making it difficultly to cure by surgery. Netrin-1, an extracellular guidance cue critical for neuronal axon path-finding, h...
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Article
Open AccessAnti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria
The widespread emergence of anti-malarial drug resistance has necessitated the discovery of novel anti-malarial drug candidates. In this study, chloroquine derivatives were evaluated for the improved anti-mala...
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Article
Open AccessBiomechanical effects of morphological variations of the cortical wall at the bone-cement interface
The integrity of bone-cement interface is very important for the stabilization and long-term sustain of cemented prosthesis. Variations in the bone-cement interface morphology may affect the mechanical respons...
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Article
Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2/M phase cell cycle arrest
The present study was performed to investigate the effect of resveratrol (trans-3,4′,5-trihydroxystilbene) present as a natural phytoalexin in grapes, peanuts, and red wine on oral squamous cancer cell lines, SCC...
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Article
An international ecological study of adult height in relation to cancer incidence for 24 anatomical sites
Anthropometric indices associated with childhood growth and height attained in adulthood, have been associated with an increased incidence of certain malignancies. To evaluate the cancer–height relationship, w...
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Article
Secretory expression of a bispecific antibody targeting tumor necrosis factor and ED-B fibronectin in Pichia pastoris and its functional analysis
Specific targeting of tumor necrosis factor (TNF)-α antagonist to the inflamed site could increase its efficacy and reduce side-effects. Here, we constructed a bispecific diabody (BsDb) that targets TNF-α and ...
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Article
Protein kinase C-δ mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages
Activations of the complement C5a (C5a) and the urokinase-type plasminogen activator (uPA) are commonly seen together during sepsis. However, the mechanism linking these two important pathways remains elusive.
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Article
Open AccessCyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1
The homeostasis of insulin-like growth factor-1 (IGF-1) is essential for metabolism, development and survival. Insufficient IGF-1 is associated with poor recovery from wounds whereas excessive IGF-1 contribute...
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Article
Erratum: CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 is a proline-directed serine/threonine kinase playing important roles in cance...
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Article
Open AccessProtein-based soft micro-optics fabricated by femtosecond laser direct writing
In this work, we report a novel soft diffractive micro-optics, called ‘microscale kinoform phase-type lens (micro-KPL)’, which is fabricated by femtosecond laser direct writing (FsLDW) using bovine serum album...
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Article
Open AccessCDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 is a proline-directed serine/threonine kinase playing important roles in cance...
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Article
Association between mandibular posterior alveolar morphology and growth pattern in a Chinese population with normal occlusion
To investigate the relationship between growth patterns and mandibular posterior tooth-alveolar bone complex morphology in a Chinese population with normal occlusion.
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Article
Establishment of reference mandibular plane for anterior alveolar morphology evaluation using cone beam computed tomography
To propose a method of establishing the reference mandibular plane (MP), which could be reestablished according to the coordinates of the reference points, and then facilitate the assessment of anterior alveol...
